Registration Dossier
Registration Dossier
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EC number: 938-094-9 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Reaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenolis a non volatile solid substance with low water solubility and low vapour pressure. Moreover,Reaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenolis an industrial chemical which is not available to general public (consumers) as such.
Exposure toReaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenolis relevant in occupational settings where the skin/eye contact with the substance may be possible.
However,Reaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenol componentsare registered antioxidants for use in a variety of consumer products, and ist major component, BHT, is also registered for use in food and feed. Therefore, evaluation of systemic toxicity ofReaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenol componentsvia oral exposure would be relevant for assessment of human health risks associated with this chemical.
In general, the main target organ for systemic toxicity of Reaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenol components is the liver. This is supported by the metabolism studies for the substance’s components.
The following systemic toxicity values were observed in studies in rodents:
2,6-di-tert-butyl-p-cresol (CAS No. 128-37-0):
NOAEL (rats, subchronic & chronic systemic toxicity) =25 mg/kg/bw/day
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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