Reaction mass of Magnesium peroxide and magnesium carbonate and magnesium hydroxide and magnesium oxide

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: There is no reference to GLP or guidelines, but the methods and results are well documented. This study is not comparable to any guideline.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1997

Materials and methods

Study type:

study with volunteers

Endpoint addressed:

acute toxicity: inhalation

Test material

Test material information

Constituent 1

Reference substance name:

Magnesium oxide

EC Number:

215-171-9

EC Name:

Magnesium oxide

Cas Number:

1309-48-4

Molecular formula:

MgO

IUPAC Name:

Magnesium oxide

Applicant's summary and conclusion

Conclusions:

There were no adverse effects noted in humans exposed to magnesium oxide particles by inhalation.

Executive summary:

Kuschner et al:

The goal of this study was to characterise human pulmonary responses to controlled experimental high-dose exposure to fine and ultrafine magnesium oxide particles. Six normal volunteers inhaled purified magnesium oxide particles. Four males and two females were examined and they were both smokers and non smokers. Measurements were obtained from the same six subjects without prior magnesium exposure for comparison. Pulmonary inflammatory cell and cytokine responses were measured 20 hours postexposure by analysis of bronchoalveolar lavage fluid. Peripheral blood neutrophil and pulmonary function 18 hours postexposure were also measured. The exposure levels tested ranged from 5.8 to 230 mg/m³ with a median magnesium concentration of 133 mg/m³, and exposure time was varied between 15 and 45 minutes.

None of the subjects documented a fever or any symptoms associated with metal fume fever. There was no overall postexposure fall in pulmonary function. Slight increases in total lung capacity and the diffusing capacity for CO were not statistically significant. There were no statistically significant differences in concentrations of BAL neutrophils, macrophages, lymphocytes, protein or increases in any of the proinflammatory cytokines studied between postexposure and paired control values. In conclusion magnesium oxide did not show any toxicity towards the six subjects tested in this experiment.