Registration Dossier
Registration Dossier
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EC number: 201-756-6 | CAS number: 87-60-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
- Author:
- Gesellschaft deutscher Chemiker
- Year:
- 1 990
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloro-p-toluidine
- EC Number:
- 202-446-3
- EC Name:
- 3-chloro-p-toluidine
- Cas Number:
- 95-74-9
- IUPAC Name:
- 3-chloro-4-methylaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Remarks on duration:
- further: 7 hours and 4 hours daily on five consecutive days
- Concentrations:
- 1.3, 1.4, and 1.76 mg/m³ air
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- > 1.76 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- > 1.76 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- > 1.76 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: daily on five consecutive days
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: At no time point of exposure the rats showed intoxication symptoms.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
