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Description of key information

No experimental toxicokinetic study is available on 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, the absorption of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid is expected to be possible by oral route, dermal route and inhalation.

Key value for chemical safety assessment

Additional information

No experimental toxicokinetic study is available on 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physico-chemical properties, including:

-Mean molecular weight: Mean 414 g/mol, range [316;795] with 85.5% < 500 g/mol

-Water solubility: 16.39 mg/L (20°C) (slightly soluble)

-Partition coefficient Log Kow: between 1.49 -4.74 (83% of the substance)

-Vapour pressure: 0.00000417 Pa (25 °C)

 

ABSORPTION

The low solubility of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid is favorable for a low oral absorption. With a moderate value of Log Kow [1,49 ; 4,74], the compound could be absorbed by oral route.

No clinical effects were observed after one single (2000 mg/kg) of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid by gavage (oral route) in rats. An oral absorption is expected to be possible for 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid.

 

With a solubility of 16.39 mg/L, dermal absorption is anticipated to be low. However, the moderate value of Log Kow and the molecular mass below 500 g/mol are favourable to a dermal absorption. The acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, the dermal absorption of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid is anticipated to be possible. In the dermal acute toxicity study, where no systemic effect or mortality were observed in rats treated with 2000 mg/kg bw. However, 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid showed allergic reaction in the LLNA: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose.

 

Based on the low value of the vapour pressure (<0.1 Pa), 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid is not a volatile substance. Moreover, the absorption by inhalation can be expected to be low for

4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid based on the values of water solubility and log kow.

 

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid.

In the 28 -day and 90 -day repeated toxicity studies, some effects on organs were observed suggesting a good distribution into the organism.

 

ELIMINATION

Due to the low water solubility and the moderate molecular mass, the excretion of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid in the urines is expected to be low. An excretion via bile and faeces is possible.