Registration Dossier
Registration Dossier
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EC number: 411-200-6 | CAS number: 14657-64-8 FYROL 3-HPP; HIRETAR-205; PHOSGARD PF 100
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: ECHA inquiry result
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 3-(hydroxyphenylphosphinyl)propanoic acid
- EC Number:
- 411-200-6
- EC Name:
- 3-(hydroxyphenylphosphinyl)propanoic acid
- Cas Number:
- 14657-64-8
- Molecular formula:
- C9H11O4P
- IUPAC Name:
- 3-[hydroxy(phenyl)phosphoryl]propanoic acid
Constituent 1
Test animals
- Species:
- other: Albino Sprague-Dawley CD rats
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: The test material was initially ground to a fine powder, then approximately 100 grams of Certified Rodent Diet was added and mixed until homogeneous. This mixture was than mixed with an appropriate amount of diet to yield the proper dose levels.
- Details on oral exposure:
- diet
- Duration of treatment / exposure:
- test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 50 mg/kg bw/day
Male: 5 animals at 250 mg/kg bw/day
Male: 5 animals at 1000 mg/kg bw/day
Female: 5 animals at 0 mg/kg bw/day
Female: 5 animals at 50 mg/kg bw/day
Female: 5 animals at 250 mg/kg bw/day
Female: 5 animals at 1000 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
No mortality
The statistically significant decrease in mean alkaline
phosphatase value of the females treated with 1000 mg/kg/d
was not accompanied by changes in liver weights values or
macroscopic or microscopic changes in the liver and was not
considered to be toxicologically significant.
Laboratory findings:
No adverse effects
Effects in organs:
No treatment related macro- and microscopic findings
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day
- Dose descriptor:
- NOEL
- Effect level:
- 1 000 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- classified as : not classified
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