Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

bioaccumulation: terrestrial
Type of information:
other: expert statement
Adequacy of study:
weight of evidence
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: 1b Comparable to guideline study

Data source

Reference Type:
other: expert statement
No information
Frère F.

Materials and methods

Principles of method if other than guideline:
The attached Toxicokinetic Assessment is meant to fulfill the requirement as defined in the REGULATION (EC) No 1907/2006 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 18 December 2006 requests in Annex VIII, point 8.8.1:
"Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from therelevant available information."

Test material

Constituent 1
Reference substance name:
2-Propanol, 1,1'-[[3-[(3-aminopropyl)amino]propyl]imino]bis-, N-tallow alkyl derivs.
EC Number:
EC Name:
2-Propanol, 1,1'-[[3-[(3-aminopropyl)amino]propyl]imino]bis-, N-tallow alkyl derivs.
Cas Number:
Molecular formula:
No molecular formula
2-Propanol, 1,1'-[[3-[(3-aminopropyl)amino]propyl]imino]bis-, N-tallow alkyl derivs.

Results and discussion

Applicant's summary and conclusion

Executive summary:

The relevant available data on 2-Propanol, 1,1'-[[3-[(3-aminopropyl) amino]propyl]imino]bis-, N-tallow alkyl derivs. was analyzed to assess its potential toxicokinetic behaviour. The UVCB consists of ca. 50 different compounds. Most of the constituents are n-alkane-dipropylene triamines that are partly or fully propoxylated and contain primary, secondary or tertiary amine groups which are positively charged at in the physiological pH range. Overall the absorbance is expected to be low, while the metabolisation of amines common reactions of xenobiotic metabolism. Therefore a tendency for bioaccumulation is not expected. Metabolites will be excreted both via urine and bile (feces) depending on the size and charge of the molecules.