Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 805-675-2 | CAS number: 102340-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Deviations:
- yes
- Remarks:
- substance for positive control : the reference used is not the same than these specified in the study plan (different supplier and reference). This deviation has no effect on the test because the substance is the same
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (2S,3R,4S,5S,6R)-2-{[(2R)-2,8-dimethyl-2-[(4S,8S)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
- EC Number:
- 805-675-2
- Cas Number:
- 102340-61-4
- Molecular formula:
- C35H56O7
- IUPAC Name:
- (2S,3R,4S,5S,6R)-2-{[(2R)-2,8-dimethyl-2-[(4S,8S)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
- Test material form:
- other: semi-solid
- Details on test material:
- yellow orange semi-solid
purity : 46.8%
For technical reasons (solubility and stability of mixtures), the commercial substance is tested (50% in mixture of triglyceride capric caprylic)
Constituent 1
Test animals
- Species:
- human
Test system
- Type of coverage:
- other: in vitro assay
- Preparation of test site:
- other: in vitro assay
- Vehicle:
- other: paraffine oil
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- Test item at 10% and 100%
- Duration of treatment / exposure:
- Treatment : 42 min
Post-incubation : 42 h - Number of animals:
- 3 per assay
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 100
- Remarks on result:
- other:
- Remarks:
- Basis: other: test assay 1 (10%). Time point: treatment : 42 minutes and revovery period : 42 hours. (migrated information)
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 100
- Remarks on result:
- other:
- Remarks:
- Basis: other: test assay 2 (100%). Time point: treatment : 42 minutes and revovery period : 42 hours. (migrated information)
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 1.4
- Remarks on result:
- other:
- Remarks:
- Basis: other: positive control. Time point: treatment : 42 minutes and revovery period : 42 hours. (migrated information)
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 3.3
- Remarks on result:
- other:
- Remarks:
- Basis: other: negative control (PBS). Time point: treatment : 42 minutes and revovery period : 42 hours. (migrated information)
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 10
- Remarks on result:
- other:
- Remarks:
- Basis: other: negative control (paraffine oil). Time point: treatment : 42 minutes and revovery period : 42 hours. (migrated information)
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the experimental conditions used, the test item at the concentrations 10% and 100% is not irritant on SkinEthic skin irritation test.
- Executive summary:
The aim of the study was to evaluate teh skin irritation potential of the test item Tocopheryl Glucoside.
The study was conduced on reconstructed human epidermis (SkinEthic skin irritation test) according OECD guideline n°439.
Culture cells were exposed to test item at 10% and 100% during 42 minutes and the viability was meseared using MTT coloration test.
In the test conditions used, the test item at 10% and 100%, corresponding to tocopheryl Glucoside concentration at 4,68 and 46,8%, was not irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.