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EC number: 229-554-3 | CAS number: 6607-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 18 - June 7, 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD), GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- (March 22 1996)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Department of toxicolgy, BASF AG
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,3,7,8-tetrahydro-2,5,8-benzotrioxacycloundecine-1,9-dione
- EC Number:
- 229-554-3
- EC Name:
- 2,3,7,8-tetrahydro-2,5,8-benzotrioxacycloundecine-1,9-dione
- Cas Number:
- 6607-34-7
- Molecular formula:
- C10H16O5
- IUPAC Name:
- 1,4,7-Trioxacyclotridecane-8,13-dione
- Details on test material:
- - Name as cited in report: Adipic acid, cyclic ester with diethyleneglycol
- Analytical purity: ca. 90%
- Physical state: Solid/white
- Storage: refrigerated
- Lot/batch No.: B 74
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar (SPF)/CrI:WI (GLX/BRL/HAN) IGS BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Deutschland, Sandhofer Weg 7, 97633 Sulzfeld
- Age at study initiation: Male (approx. 8 - 12 weeks), Female (approx. 12 - 18 weeks)
- Weight range at study initiation: Male (162 - 173 g), Female (161 - 169 g)
- Fasting period before study: 16 h
- Housing: singly
- Diet: ad libitum, Kliba Labordiaet (the feed was assayed for chemical and microbiological contaminants)
- Water: ad libitum, tap water (drinking water is regularly assayed for chemical and microbiological contaminants)
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
VEHICLE
- Justification for choice of vehicle: Aqueous formulation corresponded to the physiological medium.
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
CLASS METHOD
- Rationale for the selection of the starting dose:
Based on the physical and chemical characteristics of the test substance and its composition, no pronounced acute oral toxicity was expected. Therefore, a starting dose of 2,000 mg/kg bw (limit test) was chosen in the first step with 3 female animals. As none of those animals died, 2,000 mg/kg bw were administered to 3 male animals in a second step. No mortalities were also observed. Because no mortality occurred, either study fulfilled the criteria for a limit test and was terminated. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs of toxicity and symptoms were recorded several times on the day of administration, at least once each workday for the individual animals. Individual body weights were taken shortly before application (day 0, before fasting period), after 1 week and at the end of the study. Mortality and moribund animals were checked for twice a day on work days, and once on Saturdays and Sundays and on public holidays
- Necropsy of survivors performed: yes
Gross-pathology examination were perfomed on the last day of the observation period. Withdrawal of food was performed at least 16 hours before killing with CO2.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality occured
- Clinical signs:
- No signs of toxicity were observed in males and female animals during the clinical examination.
- Body weight:
- Mean body weights increased for both genders through out the study period (see table below).
- Gross pathology:
- No macroscopic pathologic abnormalities were noted in the animals (3 males and 3 females) examined at termination of the study.
Any other information on results incl. tables
Mean Body Weight:
Day 0 |
Day 7 |
Day 13 |
|
Male |
169 g |
205 g |
221 g |
Female |
167 g |
185 g |
190 g |
Under the conditions of this study the median lethal dose of the test substance after oral administration was found to be greater than 2,000 mg/kg body weight for male and female rats.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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