Registration Dossier
Registration Dossier
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EC number: 700-340-6 | CAS number: 76524-94-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a study according to OECD guideline 429 the test item Y-15864 was assessed for its possible skin sensitising potential by a local lymph node assay (LLNA). Concentrations of 25%, 50% (w/v), and 100% (undiluted test item) were administered to 4 CBA mice per group. The animals did not show any signs of systemic toxicity or local skin irritation during the course of the study and no cases of mortality were observed. Stimulation Indices (S.I.) of 1.24, 4.68, and 14.81 were determined with the test item at concentrations of 25%, 50% (w/v), and 100% (undiluted test item) in acetone:olive oil (4+1 v/v), respectively. A clear dose response was observed. The test item Y-15864 was found to be a skin sensitiser and an EC3 value of 37.8% (w/v) was derived.
Migrated from Short description of key information:
LLNA with CBA mice: sensitising
Justification for classification or non-classification
Y-15864 was found to be a skin sensitiser with EC value > 2 and has therefore to be classified according to:
DSD: Sensitising, R43
CLP: Skin sensitiser Cat. 1B, H317
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