Registration Dossier
Registration Dossier
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EC number: 205-592-6 | CAS number: 143-22-6
Immunotoxicity
Administrative data
Description of key information
There are conclusive but not suffcient data for the classification of substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol with regard to Immunotoxicity.
Key value for chemical safety assessment
Effect on immunotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 768.1 mg/kg bw/day
Effect on immunotoxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 33.4 mg/m³
Effect on immunotoxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 746 mg/kg bw/day
Additional information
Oral exposure
The substance triethylene glycol butyl ether (TEGBE or 2 -(2 -(2 butoxyethoxy)ethoxy)ethanol, the subject of this dossier) is expected to exhibit very similar toxicity due to its close structural similarity to 2 -butoxyethanol Comparable metabolism would occur.
On a molecular weight scaled basis, the NOAELwould be768.1mg/kg bw day.
(440x 206.28) /118.17=768.1mg/kg bw/day
dermal exosure
The substance triethylene glycol butyl ether (TEGBE or 2 -(2 -(2 butoxyethoxy)ethoxy)ethanol, the subject of this dossier) is expected to exhibit very similar toxicity due to its close structural similarity to 2 -butoxyethanol Comparable metabolism would occur.
On a molecular weight scaled basis, the NOAEl would be 1746 mg/kg bw daw.
(1000x 206.28) /118.17=1746 mg/kg bw/day
Inhalation exposure:
The oral dose for the rat is converted to the corresponding air concentration using a standard breathing volume for the rat (1.15 m3/kg for 24 hours exposure. The resulting air concentration needs to be additionally corrected for 24 hlight activity (20 m3), assuming 100 % absorption for both routes.
NOAEL rat = 768.1mg/kg bw/day
÷1.15 m3/kgbw
÷20m3/rat
NOAECrat = 33.4 mg/m3
Justification for classification or non-classification
There are conclusive but not suffcient data for the classification of substance 2-(2-(2-butoxyethoxy)ethoxy)ethanolwith regard to immunotoxicity
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