A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

December 22, 1992 - December 30, 1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study has been performed according to OECD 105 (1981), EU Method A.6 (1984) and according to GLP principles. Limited information available to verify the composition of the used test substance.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

(1981)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

(1984)

Deviations:

no

GLP compliance:

yes

Type of method:

column elution method

Test material

Test material information

Constituent 1

Reference substance name:

A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene

EC Number:

411-070-0

EC Name:

A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene

Molecular formula:

C23H24N4O2

IUPAC Name:

3-(2-methyl-5-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea

Details on test material:

- Name of test material (as cited in study report): KY-ET
- Appearance: Light yellow solid
- Storage condition of test material: At room temperature in the dark

Results and discussion

Water solubility

Water solubility:

< 2 µg/L

Temp.:

20 °C

pH:

6

Details on results:

- In most of the chromatograms of the water samples from both the preliminary test and the main study, no significant test substance peaks were observed. Hence, the water solubility of all the constituents and impurities of KY-ET was determined to be below the limit of detection.
- Using the standard solutions from the quantitative analyses, the limit of detection was determined on each day of analysis
- The limit of detection was determined to be < 2 µg/L
- The chromatograms of the samples taken from the blank column at 20 degrees Celsius did not show any peak with the same retention as the substance

Any other information on results incl. tables

Results of preliminary test

- The water solubility estimated from the preliminary test was < 1 µg/L at 20 degrees Celsius

Results of the main test: first experiment (Column 1)

Flowrate [mL/hour]	Sample no	Concentration [µg/L]	Mean at 1 flowrate [µg/L]	Mean [µg/L]	pH
24	1	4*	< 2	< 2	6.0
	2	< 2
	3	< 2
	4	< 2
	5	< 2
	6	< 2
	7	< 2
12	1	2*	< 2		6.0
	2	< 2
	3	< 2
	4	< 2
	5	< 2
	6	< 2
	7	< 2

Results of the main test: second experiment (Column 2)

Flowrate [mL/hour]	Sample no	Concentration [µg/L]	Mean at 1 flowrate [µg/L]	Mean [µg/L]	pH
24	1	< 2	< 2	< 2	6.0
	2	< 2
	3	< 2
	4	< 2
	5	< 2
	6	< 2
	7	< 2
12	1	2	< 2		6.0
	2	< 2
	3	< 2
	4	< 2
	5	< 2
	6	< 2
	7	< 2

 

*Not taken into account as the value is out of range

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
Using the column elution method the water solubility of the substance was determined in accordance with OECD 105 (1981), EU Method A.6 (1984) and according to GLP principles. The water solubility of the substance was determined to be < 2 µg/L at 20 degrees Celsius.