Registration Dossier
Registration Dossier
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EC number: 401-990-0 | CAS number: 106990-43-6 CHIMASSORB 119; LOWILITE 19
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The OECD Guideline 417 (Toxicokinetics) was followed in oder to obtain information on the absorption, distribution and excretion (ADE) of the substance in the male rat after oral administration. Doses: 50 and 1000 mg/kg bw
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The excretion of total radioactivity is virtually complete within 96 hours after administration, radioactivity is excreted nearly entirely via faeces (96-99% of recovered radiolabel).
Renal excretion is very low (0.28 - 0.60% of the dose), and excretion of radioactivity via expired air negligible (<= 0.01% of the dose). There is hardly any retention of radioactivity in tissues. There was no significant bioconcentration or accumulation in any of the organs investigated.
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