Registration Dossier

Administrative data

Endpoint:
developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
2011
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The reliability can not be assessed because the model documentation is not yet detailed enough to allow a proper assessment.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: report of QSAR model
Title:
CAESAR QSAR model for Developmental Toxicity, DEX-2
Year:
2011
Bibliographic source:
CAESAR QSAR model for Developmental Toxicity, version 1.0.0.10

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Structure-activity relationship assessed in silico ((Q)SAR) model.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

The model output shows that the substance could be a developmental toxicant.

Applicant's summary and conclusion

Conclusions:
The model output shows that the substance could be a developmental toxicant. However, the study is disregarded because the reliability can not be assessed (the model documentation is not yet detailed enough to allow a proper assessment).