Registration Dossier
Registration Dossier
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EC number: 227-877-4 | CAS number: 6022-22-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only short summary available. Procedure follows OECD testing guideline as far as can be derived from results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- limited reporting details on results
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium 4,4'-diamino-9,9',10,10'-tetrahydro-9,9',10,10'-tetraoxo[1,1'-bianthracene]-3,3'-disulphonate
- EC Number:
- 227-877-4
- EC Name:
- Disodium 4,4'-diamino-9,9',10,10'-tetrahydro-9,9',10,10'-tetraoxo[1,1'-bianthracene]-3,3'-disulphonate
- Cas Number:
- 6022-22-6
- Molecular formula:
- C28H16N2O10S2.2Na
- IUPAC Name:
- disodium 4,4'-diamino-9,9',10,10'-tetraoxo-9,9',10,10'-tetrahydro-1,1'-bianthracene-3,3'-disulfonate
- Details on test material:
- - Purity: 82.9 %
- Lot/batch No.: EN 901700.99
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- young adult albino rats were used. No further details available.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- None given
- Doses:
- 200 and 2000 mg/kg
- No. of animals per sex per dose:
- - 200 mg/kg: 3 female animals;
- 2000 mg/kg: 3 female animals; 3 male animals; - Control animals:
- no
- Details on study design:
- - Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Piloerection, hunched posture, and dyspnea were seen, being common symptoms in acute toxicity testing. The animals recovered within 3 to 5 days.
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Piloerection, hunched posture, and dyspnea were seen, being common symptoms in acute toxicity testing. The animals recovered within 3 to 5 days.
- Gross pathology:
- At autopsy, no deviations from normal morphology were found.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
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