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EC number: 692-721-8 | CAS number: 757251-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity in vitro
The mutagenic potential of AFP-Picolinmethylamid was evaluated in a Salmonella/microsome test with the S. typhimurium strains TA 98, TA 100, TA 102, TA 1535 and TA 1537 in the presence and absence of S9 mix according to OECD TG 471 (Herbold, 2007). Doses up to and including 2400 µg per plate did not cause any bacteriotoxic effects. Total bacteria counts remained unchanged and no inhibition of growth was observed. At higher doses, the substance had only a weak, strain-specific bacteriotoxic effect. Due to the weakness of this effect this range could nevertheless be used for assessment purposes.Evidence of mutagenic activity of AFP-Picolinmethylamid was seen. On Salmonella typhimurium TA 100 and TA 98, a biologically relevant increase was found in the mutant count compared to the corresponding negative control. Positive response was found only with S9 mix. The lowest effective dose was 50 µg per plate for TA 100 and 300 µg per plate for TA 98. The Salmonella/microsome test thus showed AFP-Picolinmethylamid to have a mutagenic effect.
Genetic toxicity in vivo
Evaluation of the Micronucleus test data did not show any evidence for a mutagenic potential of AFP-Picolinmethylamid (BAY 74-2329) in male and female rats when administered intragastrically up to the toxic dose level of 500 mg/kg bw (Rothfuß and von Wedel, 2011). It is therefore concluded that AFP-Picolinmethylamid is non-mutagenic in the rat bone marrow Micronucleus test according to OECD TG 474.
Evaluation of the liver Comet Assay data obtained in the low dose study showed that treatment with AFP-Picolinmethylamid (BAY 74-2329) at doses up to 60 mg/kg did not produce any evidence for genotoxicity in the rat liver Comet Assay (Rothfuß and von Wedel, 2011). However, data obtained in the high dose liver Comet Assay demonstrated a weak potential of AFP-Picolinmethylamid to induce primary DNA damage in the liver of male and female rats after treatment with 125 mg/kg AFP-Picolinmethylamid and higher. Thus, AFP-Picolinmethylamid is considered as a weak genotoxin in the rat liver Comet Assay.
Justification for selection of genetic toxicity endpoint
Only one study available each for Ames test, micronucleus test and liver comet assay
Short description of key information:
Salmonella/microsome test (Ames test): positive with strains TA 98 and TA 100 (+ S9 mix) and negative with strains TA 102, TA 1535 and TA 1537 (+/- S9 mix)
Bone marrow micronucleus test: negative up to 500 mg/kg bw.
Liver comet assay: weak potential to induce primary DNA damage at 125, 250 and 500 mg/kg bw.
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC or Regulation (EC) No. 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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