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EC number: 603-837-5
CAS number: 134605-64-4
Weight of evidence:Low mobility in soil under aerobic conditions, Directive 95/36/EC, Brandelli 2001a.Rapid degradation under aerobic conditions, half-life between 0.8 and 1.3 days, Directive 95/36/EC, Schulze-Aurich 1998.Rapid degradation under aerobic conditions, half-life between 2.9 and 27.0 days, Directive 95/36/EC, Brandelli 2001b.Rapid degradation under aerobic conditions, half-life between 0.6 and 1.1 days, Directive 95/36/EC, Ellgenhause & Morgenroth 1998.Rapid degradation under aerobic/anaerobic conditions, half-lives ranged from 0.448 to 2.20 days, EPA 162-2 & 162-3, Geldhill 2001.Low potential for bioaccumulation under anaerobic, half-lives ranged from 0.4 to 1.7 days, EPA 162-3, Spare 2000.Rapid degradation under aerobic-anaerobic conditions, half-lives ranged from 0.5 to 6.2 days, Directive 95/36/EC, Morgenroth 1999.Rapid degradation under aerobic/anaerobic conditions, half-lives ranged from 0.5 to 3.4 days, Directive 95/36/EC, Ellgenhausen 1999.Rapid bi-phasic degradation under aerobic conditions, primary half-life 0.6 days, secondary half life 220 days, EPA 162-1, Scott 1998.Rapid metabolism under aerobic conditions, primary half-life 0.62 to 0.52 days, secondary half-life between 189.90 and 341.45 days, EPA 162-1, Cruz 1997.
Ten studies have been provided on a weight of evidence basis. The
consensus of which is that the test material has a low mobility in soil,
degrades rapidly and has little potential for bioaccumulation. The
half-life of the test material is bi-phasic, where <90 % is degraded
within the primary phase of approximately 0.6 days. The secondary phase
was much slower ranging from 189.90 341.45 days. Degradation was
considered to be dependent on microbial viability of the soil, where the
fasted degradations were observed in viable, moist, aerobic soils
incubated at ambient temperature. Several major and minor degradated
Brandelli (2001a) demonstrated that the test material has a low mobility
in soil, with a penetration depth of between 5 and 10 cm into the soil
columns. Three metabolites major metabolites were identified, one in the
soil and three in the leachate. Only small amounts of radioactivity were
detected in the leachate (between 0.0 to 29.0 %), consisting of
degradation compounds only.
Schulze-Aurich (1998) determined that the test material degraded rapidly
in the three soils under aerobic conditions, with a half-life ranging
from 0.8 to 1.3 days. Three major metabolites were identified, with
half-lives ranging from 2.1 to 53.8 days.
Brandelli (2001b) determined that the test material rapidly degraded in
biologically active soils with half-lives ranging from 2.9 to 27.0 days.
Representing a much reduced persistency in all three soils. Three major
metabolites were identified in the three soils during incubation,
although there profiles displayed variation between the soil types.
Ellgenhause & Morgenroth (1998) determined that the test material
rapidly degraded in soil subject to various aerobic environmental
conditions. The half-life of the test material ranged from 0.6 to 1.1
days. The half-life of the test material was unaffected by the
application rate, although a decreased soil moisture produced a slightly
longer half-life. Three main metabolites were identified with half-lives
ranging from 1.6 to 153 days under the various conditions. End products
were bound residue and carbon dioxide.
Rapid dissipation of the test material was observed under
aerobic/anaerobic conditions Geldhill (2001). The degradation profiles
of the test material were similar regardless of whether the test system
was incubated under anaerobic conditions from the start, or converted to
from aerobic to anaerobic conditions shortly after dosing. The same
three major metabolites were identified in both samples.
Spare (2000) determined that the test material degraded rapidly in the
water column and showed little potential for bioaccumulation in the soil
phase. The test material degraded with a half life of 0.4 days in the
water phase, and 1.7 days in the total system. Three major and two minor
metabolites were identified. These resulting degradation products remain
primarily with the water and show little potential for movement into the
Morgenroth (1999) determined that the test material rapidly degraded in
biologically active soil. Metabolism under aerobic conditions was faster
in comparison to anaerobic conditions, with half-lives of 0.5 and 1.9
days respectively. A reduced temperature also increased the degradation
time of the test material. No degradation occurred in sterile soil.
Degradation to the test material was thus considered to be driven mainly
by microbial degradation. In total eight metabolites were identified,
however their profiles varied under the different environmental
conditions, half-lives ranged from 2.1 to 48.1 days.
Ellgenhausen (1999) determined that the test material had a half-life of
0.5 days in aerobic incubations and a longer half-life of 3.4 days under
anaerobic conditions. Three major and seven minor metabolites were
identified in aerobic incubations with half-lives ranging from 1.6 to
6.5 days. Four minor and five major metabolites were identified in
anaerobic incubations with half-lives ranging from 15.3 to 59.7 days.
Anaerobic end products of incubation were mainly carbon dioxide and
bound residue, the latter also further degrading to form carbon dioxide.
Therefore no accumulation can be expected of the parent compound or its
aerobic and anaerobic metabolites.
Scott (1998) determined that the degradation of the test material under
aerobic conditions was bi-phasic, with primary and secondary half-lives
of 0.6 and 220 days respectively. Exposure at difference dose levels
showed no significant differences in the metabolic patterns. Three major
metabolites were identified. Calculated metabolite half-lives ranged
from 2.43 to 218.72 days.
Schocken (1996), provided as supporting information, showed that
soil-associated radioactivity accounted for an average of 104 % of the
applied dose for the samples in kinetic and degradate viable soil and
kinetic sterile soil and 100 % for the degradate sterile soil samples
after 366 days of incubation. Furthermore the production of volatiles
accounted for less than 3 % in kinetic and degradate viable samples. All
volatile radioactivity was trapped in the duplicate aqueous potassium
hydroxide traps. No significant volatile production (≤0.01 %) was
detected for either of the sterile test systems. Samples were further
analysed in Cruz (1997).
Cruz (1997) analysed soil samples incubated in Schocken (1996), and
showed that the test material was rapidly metabolised in viable soil,
regardless of the dose rate. The test material displayed bi-phasic
degradation in viable samples with a primary half-life ranging from 0.52
to 0.62 days, and a secondary half-life between 189.90 and 341.45 days.
Degradation was slower in sterile samples. Four major
metabolites were identified in viable samples, whereas only one was
identified in sterile samples. The degradation of the test material is
considered to be dependent on microbial viability of the soil.
All studies was performed to a high standard, in line with GLP and in
accordance with standardised guidelines and has thus been assigned a
reliability score of 1 in line with the principles for assessing data
quality set out in Klimisch (1997).
The available data are considered to be complete and the conclusion that
the test material is rapidly degradable in soil at 20 °C has been taken
forward for risk assessment.
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