Registration Dossier
Registration Dossier
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EC number: 601-495-1 | CAS number: 117829-74-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
1-Propanol, 3-(dimethylamino)-, hydrochloride is a 1:1 mixture of 3-Dimethylamino-propanol-1 (CAS 3179 -63 -3) and HCl. Therefore 3-Dimethylamino-propanol-1 is suitable for read across in order to evaluate genotoxicity of 1-Propanol, 3-(dimethylamino)-, hydrochloride.
Following study was done with the read across substance 3 -Dimethylamino-propanol-1:
3-Dimethylamino-propanol-1 was tested in the standard plate test (SPT) and the preincubation test (PIT) with S. typhimurium strains TA 98, 100, 1535 and 1537 as well as with E. coli WP2 uvrA according to OECD Guidelines 471 and 472 (BASF 1999). In both tests doses of 20, 100, 500, 2500 and 5000 μg/plate were tested. Both tests were performed with and without metabolic activation (Aroclor-induced rat liver S-9 mix). Negative controls with water (solvent) and a sterility control as well as positive controls were run in parallel. In both the SPT and the PIT 3 test plates per dose or per control were tested. Incubation took place at 37° C for 48-72 hours in the dark. No increase in the number of his+ or trp+ revertants was observed in the present study. Thus, the test substance is not a mutagenic agent in the bacterial reverse mutation assay test in vitro chosen for the present study. A weakly bacteriotoxic effect (reduction in the titer) was seen in the SPT with S. typhimurium at 5000 μg/plate. In the PIT bacteriotoxicity (reduced his- or trp- background growth, decrease in the number of his+ or trp+ revertants, reduction in the titer) was observed depending on the strain and test conditions from about 2500 μg/plate.
Short description of key information:
No data available for test substance.
Data from a structural similar substance is available: CAS 3179-63-3. Data from an in vitro genetic toxicity test (Ames test) showed negative results for this read across substance (BASF 1999 (40M0650/964381), OECD 471/472).
Endpoint Conclusion:
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available study are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for genetic toxicity under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data is reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for genetic toxicity under Regulation (EC) No. 1272/2008.
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