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EC number: 406-200-8 | CAS number: 117827-06-2 COUPLER II; UC-136
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1989, november 21st to 1989, november 23rd
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed according to the Test Guidelines described in the EEC Directive 84/449/EEC
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V A.8
- Principles of method if other than guideline:
- See details on method
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- other: see details of method
Test material
- Reference substance name:
- 3',5'-dichloro-4'-ethyl-2'-hydroxypalmitanilide
- EC Number:
- 406-200-8
- EC Name:
- 3',5'-dichloro-4'-ethyl-2'-hydroxypalmitanilide
- Cas Number:
- 117827-06-2
- Molecular formula:
- C24H39Cl2NO2
- IUPAC Name:
- N-(3,5-dichloro-4-ethyl-2-hydroxyphenyl)hexadecanamide
- Details on test material:
- UC-136
#70803
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- ca. 9
- Temp.:
- 25 °C
- Remarks on result:
- other: pH is not specified
- Details on results:
- Log Pow measurement according to OECD Guidelines: the log Kow is related to the capacity factor which means that the log Kow of the samples is >> than the references. This means that log pow >> 4.7
Log Pow measurement using fatty acids for calibration
In the following table the analytical results are presented :
Raw data of the duplo measurements for the reference compounds and UC-136
tr (min) k' Log k' Log Pow
t0 0.19
tetradecanoic acid 0.498 1.62 0.21 6.11
0.498 1.62 0.21 6.11
Hexadecanoic acid 0.762 3.01 0.48 7.17
0.762 3.01 0.48 7.17
Octadecanoic acid 1.213 5.38 0.73 8.23
1.214 5.39 0.73 8.23
Eicosanoic acid 1.973 9.38 0.97 9.29
1.971 9.37 0.97 9.29
UC-136#70803 1.765 8.29 0.92 9.05
1.77 8.29 0.92 9.05
Applicant's summary and conclusion
- Conclusions:
- The log Pow value of UC-136 #70803 was determined at 9.05
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