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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
PRECLINICAL TOXICOLOGY STUDIES WITH AZITHROMYCIN GENETIC TOXICOLOGY EVALUATION
Author:
AMACHER,DE, ELLIS,JH,JR, JOYCE,AJ, MUEHLBAUER,PA, TURNER,GN, WAHRENBURG,MG, HOLDEN,HE AND RAY,VA
Year:
1993
Bibliographic source:
MUTAT. RES. 300(2):79-90, 1993

Materials and methods

Principles of method if other than guideline:
Method not published
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Metabolic activation system:
Rat, liver, S9
Test concentrations with justification for top dose:
Dose: 0.002-1 UG/PLATE
Vehicle / solvent:
DMSO

Results and discussion

Test results
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative