Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report Date:
2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Water solubility
Water solubility:
ca. 12 mg/L
Temp.:
25 °C
pH:
>= 7.53 - <= 7.85
Remarks on result:
other: in pure water
Details on results:
For tabulated results refer to Table 1.

Any other information on results incl. tables

Table 1: 

Sample number

W1

W2

W3

W4

W5

W6

Amount of test item (g) dispersed in 50.0 ml of solvent

0.012

0.0103

0.0108

0.0101

0.0099

0.0110

Number of days at 30 °C

3

2

1

3

2

1

Number of days at 25 °C

1

1

1

1

1

1

Centrifugation time (minutes)

40

40

40

40

40

40

Centrifugation speed (G values)

3000

3000

3000

5000

5000

5000

pH of aqueous solution

7.85

7.66

7.60

7.84

7.70

7.53

Water solubility (mg/L)

1stdetermination

2nddetermination

Average

 

11.894

12.011

11.953

 

12.324

12.404

12.364

 

12.147

12.079

12.113

 

12.261

12.263

12.262

 

12.769

12.985

12.877

12.695

12.789

12.742

Average

12.143

12.627

Relative Standard Deviation (%)

1.6

2.4

Total average (mg/L)

12

Relative Standard Deviation (%)

2.8

 

The total average water solubility and the relative standard deviation have been quoted correct to two significant figures. 

 

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The solubility of CA 2218 has been determined in pure water at 25 °C to be:

12 mg/L
Executive summary:

The solubility of CA 2218 has been determined in pure water.

This study was performed in accordance with the OECD guideline for the testing of chemicals, number 105, 1995, the Product Properties Test Guideline, OPPTS 830.7840, 1996 USA and the EEC method A.6., Official Journal of the European Communities, 92/69/EEC, 1992. 

 

The solubility determined at 25°C in pure water is: 

 

                    12 mg/L

 

The result has been quoted correct to two significant figures.