Registration Dossier
Registration Dossier
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EC number: 203-253-7 | CAS number: 104-93-8
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Available as short summary from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- The excretion and tissue distribution of [14C]-p-methylanisole in the rat after topical application. Report to RIFM.
- Author:
- D.R. Hawkins, B.C. Mayo, A.d. Pollard and W.W. Donschak
- Year:
- 1 993
- Bibliographic source:
- cited in the RIFM/FEMA database; Location 21041
Materials and methods
- Principles of method if other than guideline:
- Assessment of excretion and tissue distribution of radioactive p-methylanisole after topical application in the rat
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methylanisole
- EC Number:
- 203-253-7
- EC Name:
- 4-methylanisole
- Cas Number:
- 104-93-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 1-methoxy-4-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): (14)C-p-methylanisole
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- (14)C-p-methylanisole
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: diethyl phthalate
- Duration of exposure:
- 6 hours
- Doses:
- - Nominal doses: 100, 320 & ca. 1000 mg/kg bw
- No. of animals per group:
- 4
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
Dressing & residual dose were removed using cotton wool swabs moistened with diethyl phthalate.
SAMPLE COLLECTION
Urine, faeces & expired air were collected for 72 hours after dose application. At this time, rats were killed & whole blood & tissues were taken for measurement of radioactivity.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Total recovery:
- Radioactivity recovered from each group of rats dosed accounted for means of about 94-97% of the (14)C-p-methylanisole administered.
Percutaneous absorptionopen allclose all
- Dose:
- 100 mg/kg bw
- Parameter:
- percentage
- Absorption:
- ca. 23 %
- Remarks on result:
- other: 72 hours
- Remarks:
- No data available given for whole blood/tissues
- Dose:
- 320 mg/kg bw
- Parameter:
- percentage
- Absorption:
- ca. 35 %
- Remarks on result:
- other: 72 hours
- Remarks:
- No data available given for whole blood/tissues
- Dose:
- 1000 mg/kg bw
- Parameter:
- percentage
- Absorption:
- ca. 57 %
- Remarks on result:
- other: 72 hours
- Remarks:
- No data available given for whole blood/tissues
Any other information on results incl. tables
1000 mg/kg bw:
Total excretion via urine: 20% of dose
Total excretion via feces: 0.05-0.17% of dose
Radioactivity in expired air: 37% of dose
Recovery from washings of treated skin after 6 hours: 36% of dose
320 mg/kg bw:
Total excretion via urine: 12% of dose
Total excretion via feces: 0.05-0.17% of dose
Radioactivity in expired air: 23% of dose
Recovery from washings of treated skin after 6 hours: 59% of dose
100 mg/kg bw:
Total excretion via urine: 12% of dose
Total excretion via feces: 0.05-0.17% of dose
Radioactivity in expired air: 11% of dose
Recovery from washings of treated skin after 6 hours: 74% of dose
At 72 hours after dosing 0.02-0.05% of the dose was in the treated skin taken from these rats after being killed.
Applicant's summary and conclusion
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