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Diss Factsheets
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EC number: 926-191-9 | CAS number: 1181221-96-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- iGloss Crosslinker (ZQ54-2211)
- IUPAC Name:
- iGloss Crosslinker (ZQ54-2211)
- Details on test material:
- - Name of test material (as cited in study report): iGloss Crosslinker (ZQ54-2211)
- Physical state: Liquid (highly viscous)/ yellowish, clear
- Analytical purity: Mn 1200 Da; Mw 1800 Da; PDI 1.5; Relative RI-area of compounds with M 250-500 Da: 1.7% and with M 250-1000 Da: 29.1%; determined with Gel Permeation Chromatography
- Lot/batch No.: 294222
- Storage condition of test material: Room temperature; no direct sunlight; protect against humidity
- Other: The test item was homogeneous by visual inspection.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH
- Age at study initiation: Approx. 5-6 months
- Weight at study initiation: 4.63 kg – 4.87 kg
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: for at least 5 days before application
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +- 3°C
- Humidity (%): 30 – 70%
- Air changes (per hr): in fully air-conditioned rooms
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: dorsolateral part of the trunk
- % coverage: 2.5 cm x 2.5 cm
- Type of wrap if used: The test patch was secured in position with a semi- occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): . The test item was removed at the end of the exposure period with Lutrol® and Lutrol® / water (1 : 1).
- Time after start of exposure: 4h
SCORING SYSTEM: according to OECD 404 guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 0.7
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: individual mean scores: 0.7 in 3/3 animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 0
- Reversibility:
- other: no effects observed
Any other information on results incl. tables
Very slight erythema (grade 1) was observed in one out of three
animal immediately after removal of the patch and persisted up to hour
48.
In two out of three animals very slight erythema (grade 1) was observed
from hour 48 until hour 72 or until study day 7, respectively.
Additionally in these animals scaling was noted from hour 48 until hour
72 or until study day 14, respectively.
The cutaneous reactions, with the exception of scaling, were reversible in one animal within 14 days after removal of the patch. In another animal the cutaneous reactions were reversible within 72 hours and in the third animal within 7 days after removal of the patch.
Mean scores over 24, 48 and 72 hours for each animal were 0.7, 0.7 and 0.7 for erythema and 0.0, 0.0 and 0.0 for edema.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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