Registration Dossier
Registration Dossier
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EC number: 233-797-0 | CAS number: 10361-82-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological and pharmacological effects of gadolinium and samarium chlorides
- Author:
- T. J. Haley, K. Raymond, N. Komesu, and H. C. Upham
- Year:
- 1 961
- Bibliographic source:
- Br J Pharmacol Chemother. 1961 December; 17(3): 526–532
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Samarium (III) chloride hexahydrate
- EC Number:
- 233-797-0
- EC Name:
- Samarium (III) chloride hexahydrate
- Cas Number:
- 10361-82-7
- Molecular formula:
- Cl3Sm
- IUPAC Name:
- samarium (III) chloride hexahydrate
- Details on test material:
- - purity 99%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- other: direct application
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- single treatment
- Observation period:
- 7 days
- Number of animals:
- 6
- Details on study design:
- Direct application of samarium chloride crystals to intact rabbit skin produced no irritation within 24 hr and no delayed reaction after 72 hr. There was a very severe reaction by abraded skin resulting in the maximum irritation index of 8 within 24 hr. No change was observed within 72 hr, and within 7 days perforating ulcers 25 to 30 mm in diameter developed with penetration through the skin to the underlying muscle layers. Inasmuch as healing did not occur, the animals were killed at 14 days. The differences in response between intact and abraded skin may be related to the liberation of nascent hydrochloric acid by tissue fluids.
Results and discussion
Any other information on results incl. tables
Only for abraded skin a score in the maximum irritation index of 8 within 24 hr is given. For rabbits with intact skin no irritation within 24 hr and no delayed reaction after 72 hr is detectable.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
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