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Diss Factsheets
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EC number: 211-623-4 | CAS number: 675-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral (OECD TG 423): LD 50 = 200- 2000 mg/kg bw (male/female)
Inhalation: No data available (waiving according to Column 2 of REACH Annex VIII (Section 8.5.3))
Dermal: No reliable data available (waiving according to Column 2 of REACH Annex VIII (Section 8.5.2))
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
- Quality of whole database:
- The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Dichloromethyl(3,3,3 -trifluoropropyl)silane hydrolyses very rapidly (half-life 12 seconds) in contact with water and moist air releasing two moles of hydrogen chloride (HCl) for one mole of parent material. It is therefore classified as corrosive and acute toxicity testing is not appropriate.
Acute Oral:
In the key acute oral toxicity study (LPT, 2002) conducted in compliance with OECD 423 (adopted in 1996), and in accordance with GLP, the test material was administered to Crl:CD rats via gavage. 2000 mg/kg bw resulted in the death of 2 /3 males within 4 days. No signs of systemic toxicity were noted at this dose level. 200 mg/kg bw resulted in the death of 1/3 males and 1/3 females within 4 days. No signs of systemic toxicity were noted at 200 mg/kg bw. The authors concluded a LD50 range of 200 -2000 mg/kg bw. However, based on the interpretation flowchart of the OECD guideline followed, the LD50 cut-off value was set at 1000 mg/kg bw.
In a supporting acute oral toxicity study (TNO, 1998) conducted in compliance with OECD 423 (adopted in 1996), and in accordance with GLP, the oral LD50 of dichloromethyl (3,3,3-trifluoropropyl)silane is considered to be between 200 and 2000 mg/kg bw, in both males and females. There is a further limited report (RL 4) of an acute oral study (DCC, 1967) equivalent or similar to the now deleted OECD 401 and which predates GLP, which identified an oral LD50 value in male mice of <1.00 ml/ kg bw. Based on a relative density of 1.25 g/ml, the LD50 (oral) is <1250 mg/kg bw.
Acute Dermal:
No reliable data are available to assess the acute dermal potential of dichloromethyl (3,3,3-trifluoropropyl)silane, however, in accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the dermal route (required in Section 8.5.3) does not need to be conducted as the substance is classified as corrosive. A reliability 4, limited report of a generally well conducted study that predates GLP, identified a estimated dermal LD50 value of 2.00 ml/kg bw for dichloromethyl (3,3,3-trifluoropropyl)silane in two albino rabbits. Severe skin irritation characterised by sloughing of skin, bleeding, fissures and serious oozing was observed in both animals.
Acute Inhalation.
No data are available to assess the acute inhalation potential of dichloromethyl (3,3,3-trifluoropropyl)silane, however, in accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the inhalation route (required in Section 8.5.2) does not need to be conducted as the substance is classified as corrosive.
Justification for selection of acute toxicity – oral endpoint
The key study was selected for assessment.
Justification for selection of acute toxicity – inhalation endpoint
In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the inhalation route (required in Section 8.5.2) does not need to be conducted as the substance is classified as corrosive.
Justification for selection of acute toxicity – dermal endpoint
In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the dermal route (required in Section 8.5.3) does not need to be conducted as the substance is classified as corrosive. However, a supporting study with limited documentation (only an abstract was available for review) indicates that mortality occurred as a result of severe local skin damage rather than systemic toxicity, and hence, classification for acute dermal toxicity is not warranted.
Justification for classification or non-classification
Based on the available key study for acute oral toxicity, dichloromethyl(3,3,3 -trifluoropropyl)silane needs to be classified as
R22 "Harmful if swallowed" according to the criteria of EU Directive 67/548/EEC, and Acute Toxic 4 (oral) under Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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