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EC number: 211-623-4 | CAS number: 675-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No reproductive toxicity data is available for dichloromethyl(3,3,3-trifluoropropyl)silane. The hazard profile of dichloromethyl(3,3,3-trifluoropropyl)silane is solely driven by the hydrolysis product HCl and can be assessed qualitatively and quantitatively by considering the amount of HCl produced by hydrolysis. Further repeated-dose animal studies should be omitted due to animal welfare.
Justification for selection of Effect on fertility via oral route:
Dichloromethyl(3,3,3-trifluoropropyl)silane (CAS 675-62-7) is a highly moisture-sensitive liquid that hydrolyses rapidly in contact with water (half-life of 8 to 12 seconds at pH 4, 7 and 9 at 1.5°C) to methyl(3,3,3-trifluoropropyl)silanediol and hydrogen chloride (HCl). As the substance is corrosive, risk management measures are in place at industrial sites to prevent the potential for human exposure to dichloromethyl(3,3,3-trifluoropropyl)silane. Due to the corrosive nature of the substance it is considered not to be either ethical or scientifically justified to perform repeated dose toxicity testing with dichloromethyl(3,3,3-trifluoropropyl)silane by any route of exposure. As an example, following repeated oral dosing, the corrosive nature of the product could affect the lining of the stomach, giving rise to hyperplasia and a subsequent reduced food intake. This would make the interpretation of any systemic findings difficult.
Justification for selection of Effect on fertility via inhalation route:
A guideline-compliant repeated-dose inhalation study should elicit systemic toxicity at the highest test concentration. Since the local corrosive effects of dichloromethyl(3,3,3-trifluoropropyl)silane would be significant, it is unlikely that any systemic effects would be seen at dose levels made sufficiently low (< 10 ppm) to prevent the known corrosive effects and/or distress in the test species.
Justification for selection of Effect on fertility via dermal route:
In accordance with Section 2 of REACH Annex XI testing for reproductive toxicity (required in Section 8.7.3) will be omitted because it is technically not feasible.
The known corrosive effects of dichloromethyl(3,3,3-trifluoropropyl)silane mean that testing via all routes at suitable dose levels would lead to severe local effects and significant distress in the test species.
Effects on developmental toxicity
Description of key information
No developmental toxicity data is available for dichloromethyl(3,3,3-trifluoropropyl)silane. The hazard profile of dichloromethyl(3,3,3-trifluoropropyl)silane is solely driven by the hydrolysis product HCl and can be assessed qualitatively and quantitatively by considering the amount of HCl produced by hydrolysis. Further repeated-dose animal studies should be omitted due to animal welfare.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Dichloromethyl(3,3,3-trifluoropropyl)silane (CAS 675-62-7) is a highly moisture-sensitive liquid that hydrolyses rapidly in contact with water (half-life of 8 to 12 seconds at pH 4, 7 and 9 at 1.5°C) to methyl(3,3,3-trifluoropropyl)silanediol and hydrogen chloride (HCl). As the substance is corrosive, risk management measures are in place at industrial sites to prevent the potential for human exposure to dichloromethyl(3,3,3-trifluoropropyl)silane. Due to the corrosive nature of the substance it is considered not to be either ethical or scientifically justified to perform repeated dose toxicity testing with dichloromethyl(3,3,3-trifluoropropyl)silane by any route of exposure. As an example, following repeated oral dosing, the corrosive nature of the product could affect the lining of the stomach, giving rise to hyperplasia and a subsequent reduced food intake. This would make the interpretation of any systemic findings difficult.
Justification for selection of Effect on developmental toxicity: via inhalation route:
A guideline-compliant repeated-dose inhalation study should elicit systemic toxicity at the highest test concentration. Since the local corrosive effects of dichloromethyl(3,3,3-trifluoropropyl)silane would be significant, it is unlikely that any systemic effects would be seen at dose levels made sufficiently low (< 10 ppm) to prevent the known corrosive effects and/or distress in the test species.
Justification for selection of Effect on developmental toxicity: via dermal route:
In accordance with Section 2 of REACH Annex XI testing for reproductive toxicity (required in Section 8.7.3) will be omitted because it is technically not feasible.
The known corrosive effects of dichloromethyl(3,3,3-trifluoropropyl)silane mean that testing via all routes at suitable dose levels would lead to severe local effects and significant distress in the test species.
Justification for classification or non-classification
In the absence of appropriate measured data, the substance is not classified for reproductive or developmental toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.