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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1989
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Follow GLP guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.52 (Acute Inhalation Toxicity - Acute Toxic Class Method)
Version / remarks:
Not specified
Principles of method if other than guideline:
Not Specified
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(1-methyl-2-propoxyethoxy)propan-2-ol
EC Number:
249-949-4
EC Name:
1-(1-methyl-2-propoxyethoxy)propan-2-ol
Cas Number:
29911-27-1
Molecular formula:
C9H20O3
IUPAC Name:
1-(1-methyl-2-propoxyethoxy)propan-2-ol
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report):Propyl Dipropasol Solvent
- Substance type: Clear, low viscosity liquid
- Analytical purity: 99%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Diet (e.g. ad libitum): ad libium
- Water (e.g. ad libitum): ad libitum
- Weight: Between 200 and 300 g

ENVIRONMENTAL CONDITIONS
No information available

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Sprague-Dawley albino rats, weighing between 200 and 300 g, are exposed to substantially saturated vapor for 6 hours. The vapor is produced by enclosing approximately 100 g of the test material in a sealed 100 to 151-liter animal chamber for approximately 18 hours (static conditions). A mixing fan periodically agitates the chamber atmosphere to aid in distribution of the vapor. Oxygen is added, as needed, for static exposures to maintain a chamber oxygen content of approximately 20%. If deaths occur, exposure times are varied to determine an LT50. Five males and 5 females are included for each exposure period.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
saturated vapor
No. of animals per sex per dose:
5 males and 5 females
Control animals:
not specified
Details on study design:
Sprague-Dawley albino rats, weighing between 200 and 300 g, are exposed to substantially saturated vapor for 6 hours. The vapor is produced by enclosing approximately 100 g of the test material in a sealed 100 to 151-liter animal chamber for approximately 18 hours (static conditions). A mixing fan periodically agitates the chamber atmosphere to aid in distribution of the vapor. Oxygen is added, as needed, for static exposures to maintain a chamber oxygen content of approximately 20%. If deaths occur, exposure times are varied to determine an LT50. Five males and 5 females are included for each exposure period.
Statistics:
Not applicable

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: LC50 > Substantially Saturated Vapor (Static)
Remarks on result:
other: LC50 > Substantially Saturated Vapor (Static)
Mortality:
No Mortality
Clinical signs:
other: No signs of toxicity
Body weight:
No data
Gross pathology:
No remarkable gross lesions were evident
Other findings:
No additional data

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Inhalation, Rat; Substantially Saturated Vapor (Static):
Males: 6.0 hours killed 0 of 5.
Females: 6.0 hours killed 0 of 5.
Executive summary:

Exposure to a statically-generated, substantially saturated vapor produced no deaths of male and female rats during or following the 6-hour test. There were no signs of toxicity evident and no remarkable gross lesions were evident at necropsy.