Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

No information on the oral route of exposure.

In a dermal absorption study of 14C-dipropylene glycol n-propyl ether (DPnP) in New Zealand White rabbits following a single 6-hour dermal exposure, a total of 86-90% of the administered radioactivity applied was recovered. The majority of the applied radioactivity, 61-72%, was recovered in the 6-hour application-site wash material, jacket, and occlusive bandage. A mean of 19% of the administered radioactivity was absorbed and detected in the feces/urine, CO2, charcoal traps, tissues, cage wash, and final cage wash. The majority (12%) of the absorbed administered dose was in the combined feces/urine sample, with evidence suggesting urine is the primary route of elimination. A total of 5% of the administered dose was recovered in the CO2 and charcoal traps. Derived radioactivity from absorbed 14C-DPnP was quickly eliminated, with the majority recovered within 24 hours of application. The data is indicative of dermal absorption of undiluted 14C-DPnP when applied dermally to rabbits.