Registration Dossier
Registration Dossier
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EC number: 204-820-1 | CAS number: 127-06-0
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The measured BCF range for fish exposed to 0.2 mg/L of the analogue, butanone oxime, was 2.8-5.8. The measured BCF range for fish exposed to 2.0 mg/L butanone oxime was 0.5-0.6.
BCF prediction using EUSES is 1.41 L/kg wet-weight for fish, based on a log Kow of 0.077. Regression based estimate of BCF via Episuite v4.11, based on a log Kow of 0.077 is 3.162 L/kg wet-weight.
Key value for chemical safety assessment
- BCF (aquatic species):
- 5.8 dimensionless
Additional information
Reliable measured bioconcentration information is not available for acetone oxime. However, reliable measured bioconcentration data is available for the analogue, butanone oxime, and is included in the dossier.
Ministry of Economic Trade and Industry of Japan (METI) (1982) conducted a reliable (Klimisch 2) GLP compliant study following OECD 305C method. The common carp (Cyprinus carpio) were exposed to 0.2 and 2 mg/L of butanone oxime for 42 days. The measured BCF range for the 0.2 mg/L exposure was 2.8-5.8. The measured BCF range for the 2.0 mg/L exposure was 0.5-0.6. Therefore, these values will be taken for the bioaccumulation in fish endpoint.Based on results of this study and the measured low log Kow of 0.077, bioaccumulation of the test substance is not expected. Elementis (2013) provided reliable modeled BCF results for acetone oxime using QSAR models. BCF prediction using EUSES is 1.41 L/kg wet-weight for fish, based on a log Kow of 0.077. Regression based estimate of BCF via Episuite v4.11, based on a log Kow of 0.077 is 3.162 L/kg wet-weight.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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