Registration Dossier
Registration Dossier
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EC number: 617-040-5 | CAS number: 80286-58-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: other: gene mutation and chromosome aberration
- Type of information:
- other: data from the safety data sheet
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2011
Materials and methods
- Principles of method if other than guideline:
- Not available
- GLP compliance:
- not specified
- Type of assay:
- other: Ames test and micro-nucleus assay
Test material
- Reference substance name:
- 2-[(1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-enoic acid
- EC Number:
- 617-040-5
- Cas Number:
- 80286-58-4
- Molecular formula:
- C15H22O2
- IUPAC Name:
- 2-[(1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-enoic acid
Constituent 1
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: Bacteria for Ames test
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- other: Cell line for in vitro micro nucleus assay
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The genotoxicity Arteminisic acid is reported to be negative in Ames and in vitro micro-nucleus tests.
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