Registration Dossier

Diss Factsheets

Toxicological information

Carcinogenicity

Currently viewing:

Administrative data

Description of key information

The available read across data and available weight of evidence demonstrate that Hydrocarbons, C14-C15, n-alkanes, <2% aromatics is highly unlikely to be carcinogenic and is not classifiable as a carcinogen. Further testing is not required under Annex XI, section 1.2.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

These findings do not warrant the classification of Hydrocarbons, C14-C15, n-alkanes, <2% aromatics as a carcinogen under the CLP Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures.

Additional information

Hydrocarbons, C14-C15, n-alkanes, <2% aromatics is not genotoxic and is not classifiable as a mutagen based upon the results of reliable read-across in vitro and in vivo studies. In bacterial reverse mutation studies, C14 -C17, n-alkanes, <2% aromatics were not mutagenic in the presence or absence of metabolic activation (IUCLID section 7.6.1). In mammalian cells in vitro there were no mutagenic, clastogenic or aneugenic effects reported in read-across from studies on hydrodesulfurized kerosene kerosene: a negative chromosome aberration (Human Peripheral Lymphocyte Chromosomal Aberration Test, Chinese Hamster Ovary Sister Chromatid Exchange Assay) (IUCLID section 7.6.1).