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Diss Factsheets
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EC number: 202-854-1 | CAS number: 100-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Hippuric acid excretion after benzylamine ingestion in man
- Author:
- Wood SG et al.
- Year:
- 1 978
- Bibliographic source:
- British Medical Association, Tavistock Square, London WC1H9JR
- Reference Type:
- publication
- Title:
- Benzylamine metabolism
- Author:
- Wood SG et al.
- Year:
- 1 978
- Bibliographic source:
- The chemical environment- Fd Cosmet. Toxicol. Vol 17, no.5
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- The fate of 14C-benzylamine after oral administration as the hydrochloride has been investigated in two human male volunteers.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzylamine
- EC Number:
- 202-854-1
- EC Name:
- Benzylamine
- Cas Number:
- 100-46-9
- Molecular formula:
- C7H9N
- IUPAC Name:
- 1-phenylmethanamine
- Details on test material:
- Radiolabelled benzylamine in the form of (methylene-14C) benzylamine hydrochloride (specific activity 56 nCi/mmol). The total radioactivity was diluted with distilled water to give a final solution containing 1.00 µCi/mL. Unlabelled benzylamine hydrochloride was prepared by the dropwise addition of concentrated hydrochloric acid to a stirred solution of benzylamine in ether.
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- human
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Each 14C-benzylamine hydrochloride dose was prepared by dissolving unlabelled benzylamine hydrochloride (100 mg) in 20 mL (10 µCi) aqueous 14C-benzylamine.
- Duration and frequency of treatment / exposure:
- single administration
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Each 14C-benzylamine hydrochloride dose was prepared by dissolving unlabelled benzylamine hydrochloride (100 mg) in 20 mL (10 µCi) aqueous 14C-benzylamine.
Results and discussion
Any other information on results incl. tables
The fate of 14C-benzylamine after oral administration as the hydrochloride has been investigated in two male volunteers. Over 98% of the administered radiolabel was excreted in the urine as 14C-hippuric acid within 24 hours. The rate of urinary hippuric acid excretion was extremely rapid, with more than 90% of the dose excreted after three hours.
Urinary excretion of radioactivity following an oral dose of 14C-benzylamine hydrochloride
Subject | Time (hr) | Total urine volume (ml) | radioactivity excreted per time interval (%dose) | Cumulative radioactivity excreted (% dose) |
A | 0.5 | 20 | 66.55 | 66.55 |
1 | 16 | 17.62 | 84.17 | |
2 | 64 | 9.55 | 93.72 | |
3 | 45 | 2.42 | 96.14 | |
4 | 34 | 1.14 | 97.28 | |
5 | 25 | 0.49 | 97.77 | |
6 | 25 | 0.37 | 98.14 | |
7 | 25 | 0.23 | 98.37 | |
8 | 24 | 0.18 | 98.55 | |
10 | 50 | 0.20 | 98.75 | |
12 | 105 | 0.16 | 98.91 | |
24 | 630 | 0.29 | 99.20 | |
B | 0.25 | 50 | 3.02 | 3.02 |
0.50 | 83 | 25.26 | 28.28 | |
1 | 92 | 37.84 | 66.12 | |
2 | 122 | 20.07 | 86.19 | |
3 | 130 | 4.56 | 90.75 | |
4 | 112 | 2.37 | 93.12 | |
5 | 90 | 1.29 | 94.42 | |
6 | 57 | 0.86 | 95.28 | |
7 | 39 | 0.57 | 95.85 | |
8 | 28 | 0.38 | 96.23 | |
9 | 36 | 0.33 | 96.56 | |
10 | 47 | 0.29 | 96.85 | |
12 | 120 | 0.35 | 97.20 | |
24 | 940 | 0.93 | 98.13 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.