Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Manufacturer/producer data without proof.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2008

Materials and methods

Principles of method if other than guideline:
No data referring to the test method were reported.

GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl cyanoacetate
EC Number:
203-288-8
EC Name:
Methyl cyanoacetate
Cas Number:
105-34-0
Molecular formula:
C4H5NO2
IUPAC Name:
methyl 2-cyanoacetate
Details on test material:
no details on test material as used in the original study are available.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 062 mg/kg bw
Remarks on result:
other: no more data available

Any other information on results incl. tables

According to a MSDS by Sigma-Aldrich, the LD50 for acute oral toxicity of methyl cyanoacetate in rat is 3062 mg/kg bw.

Applicant's summary and conclusion