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EC number: 237-358-4 | CAS number: 13762-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jul. 30 - Sep. 10, 2015; experimental phase: Aug. 4-19, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1987
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- Version / remarks:
- 2004
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Cobalt molybdate
- EC Number:
- 237-358-4
- EC Name:
- Cobalt molybdate
- Cas Number:
- 13762-14-6
- Molecular formula:
- CoMoO4
- IUPAC Name:
- λ²-cobalt(2+) dioxomolybdenumbis(olate)
- Details on test material:
- - Name of test material (as cited in study report): cobalt molybdenum oxide
- Physical state: light green powder
- Analytical purity: 99%
- Batch No.: EH 110005/1
- Expiration date of the lot/batch: June 2013
- Storage condition of test material: The test item was stored in a closed vessel at room temperature.
Constituent 1
- Specific details on test material used for the study:
- Test Item: Cobalt Molybdenum Oxide
Lot Number: EH 110005/1
Certificate: Test Item Specification of LAUS GmbH
Manufacturer: Grace GmbH & Co. KG
Appearance: Light green powder
Composition: 99 % Cobalt (II) molybdenum oxide
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: Velaz Prague, Czech Republic
Age at First Dose: 8-12 weeks; female animals were non-pregnant and nulliparous
Animal Health: The health condition of animals was examined by a veterinarian before initiation of the study.
Acclimation: The animals were acclimated to the condition identical to the conditions during the experiment 5 days prior to the start of treatment. The acclimation was according to the standard operation procedure.
Housing Condition: The animals were housed in plastic cages suspended on stainless steel racks, up to 2-3 animals per cage, males and females separately in a room equipped with central air-conditioning. The room temperature was maintained within the range of 22 ± 2° C, relative humidity within 55 ± 10 %. The light regimen was set to a 12-hour light /12-hour dark cycle. The sanitation was performed according to the standard operation procedures.
Diet: A laboratory food Altromin (Altromin Spezialfutter GmbH, Germany) was offered in recommended doses each day approximately at the same time. The certificate of analysis is included in the raw data.
Water: The animals received tap water for human consumption. Supply of drinking was unlimited. The quality of drinking water is periodical analysed (including microbiological control) and recorded; certificate of analysis is included in raw data.
Bedding: Lignocel S3/4, Lufa - ITL GmbH, Germany
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on dermal exposure:
- Approximately 24 hours before the test, fur was removed from the dorsal area of the trunk of the test animals by clipping and shaving. A precise amount of the test item was aspirated into an adjustable pipette and application directly on the shaved skin of back in a single dose uniformly on
over an area approximately 10 % of the total body surface area. Test item was held in contact with the skin by using a Cosmopor E and a semi-occlusive dressing with non-irritating tape throughout the 24-hours exposure period. At the end of the exposure period, any residuals of the test item were removed by using lukewarm water without altering the existing response or integrity of the epidermis. - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- Available information indicated test item is likely to be nontoxic considering to acute toxicity. Therefore, a limit dose of 2000 mg/kg was used as starting dose. One female was dosed. Test item-related mortality was not produced during 24-hours exposure period. The sighting study was finished; the main test was started with dose of 2000 mg/kg. An additional 4 females and 5 males were dosed in the Main Study with the dose of 2000 mg/kg.
Results and discussion
- Preliminary study:
- No real preliminary study, but only one animal was dosed in the beginning (cf. above: Details on study design):
Available information indicated test item is likely to be nontoxic considering to acute toxicity. Therefore, a limit dose of 2000 mg/kg was used as starting dose. One female was dosed. Test item-related mortality was not produced during 24-hours exposure period. The sighting study was finished.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no mortality
- Clinical signs:
- other: No important signs of toxicity were observed during the first 4 hours neither in females nor in males or in 14 days observation period.
- Gross pathology:
- All animals (5 females and 5 males) were necropsied. During necropsy, no macroscopically changes were noticed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The limit dose of 2000 mg/kg did not cause death, evident symptoms of toxicity or important body weight losses during the 14 days long observation period.
Therefore, classification is not warranted. - Executive summary:
The purpose of the study was to evaluate the potential toxic effect of the test item Cobalt Molybdenum Oxide when applicate as a single dermal dose to Wistar rats. The procedure according to OECD Guideline 402 Acute Dermal Toxicity and OECD Proposal for a New Draft Guideline 434: Acute Dermal Toxicity-Fixed Dose Procedure was used.
A limit dose of 2000 mg/kg was used as starting dose. One female was dosed. Test item-related mortality was not produced during 24 hours. A total of five female rats were dosed with a limit dose of 2000 mg/kg. An additional group of 5 males was tested at the same dose.
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