Registration Dossier
Registration Dossier
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EC number: 200-945-0 | CAS number: 76-22-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Bornan-2-one
- EC Number:
- 200-945-0
- EC Name:
- Bornan-2-one
- Cas Number:
- 76-22-2
- Molecular formula:
- C10H16O
- IUPAC Name:
- 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
- Test material form:
- solid: crystalline
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: TA97a, TA98, TA100 and TA102
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 0, 50, 100, 250, 500, 750, 1000, 1250, 1500, 2000, 2500 μg/plate
- Vehicle / solvent:
- ethanol
Results and discussion
Test results
- Species / strain:
- other: TA102, TA100, TA98 and TA97a
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In conclusion, results from the present study thus suggest that citral, citronellal, (±)-camphor, (-).-menthol and 1,8-cineole are not mutagenic in the
Ames test and that terpineol is weakly mutagenic to TA102 tester strain.
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