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EC number: 217-316-1 | CAS number: 1809-19-4
Table: Results for erythema and oedema.
The skin irritation potential of the substance was evaluated in an in vivo experimental study similar to the OECD Guideline 404. The test item was applied as is to both an intact site and an abraded site of six New Zealand white rabbits, and the sites were monitored for erythema and oedema according to the Draize scale, at 24 and 72 hours after application.
All six animals demonstrated an erythema score of 4.0 at both the 24 hour and the 72 hour monitoring of both the intact and the abraded skin sites. Four out of the six animals demonstrated an oedema score of 3.0 at 24 hours on both the intact and abraded sites; the remaining two animals had a score of 4.0 at the same sites and times. At 72 hours, all six animals demonstrated an oedema score of 2.0 at both the intact and abraded sites. Reversibility of erythema and oedema was not monitored beyond 72 hours in this study. Based on these findings, the substance is considered irritating to rabbit skin.
For evaluation using the CLP regulation, it is necessary to calculate the mean erythema and oedema scores at 24, 48 and 72 hours for each animal at the intact site only. As no data for the 48 hour interval was recorded in this study, the mean was calculated using a worst-case approach, whereby the more severe of the 24 or 72 hour scores in place of the 48 hour score. The mean (24/48/72 h) erythema scores were 4.0 for all 6 animals; the mean (24/48/72 h) oedema scores were 2.67 for 4 animals, and 3.33 for 2 animals.
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