Registration Dossier
Registration Dossier
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EC number: 202-645-5 | CAS number: 98-17-9
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
EPI-SUITE EPA (USA)
2. MODEL (incl. version number)
BIOWIN v4.10
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
SMILES: Oc1cccc(c1)C(F)(F)F
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The QMRF is available in "Attached justification"
5. APPLICABILITY DOMAIN
The QPRF is available in "Attached justification"
6. ADEQUACY OF THE RESULT
The QPRF is available in "Attached justification" - Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Howard, P.H., Boethling, R.S., Stiteler, W.M., Meylan, W.M., Hueber, A.E., Beauman, J.A., Larosche, M.E. 1992. Predictive model for aerobic biodegradability developed from a file of evaluated biodegradation data. Environ. Toxicol. Chem. 11:593-603.Howard, P.H., Boethling, R.S., Stiteler, W.M., Meylan, W.M., Hueber, A.E., Beauman, J.A., Larosche, M.E. 1992. Predictive model for aerobic biodegradability developed from a file of evaluated biodegradation data. Environ. Toxicol. Chem. 11:593-603.
- GLP compliance:
- no
- Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The substance is predicted to be not readily biodegradable.
- Executive summary:
The substance is predicted to be not readily biodegradable (EPI-Suite BIOWIN v4.10).
Reference
Probability of Rapid Biodegradation (BIOWIN v4.10):
Biowin1 (Linear Model Prediction) : Does Not Biodegrade
Fast (0.2658)
Biowin2 (Non-Linear Model Prediction): Does Not Biodegrade Fast (0.0171)
Biowin3 (Ultimate Biodegradation Timeframe): Weeks-Months (2.3843)
Biowin4 (Primary Biodegradation Timeframe): Days-Weeks (3.3791)
Biowin5 (MITI Linear Model Prediction) : Not Readily Degradable (0.3791)
Biowin6 (MITI Non-Linear Model Prediction): Not Readily Degradable
(0.0000)
Biowin7 (Anaerobic Model Prediction): Biodegrades Fast (0.5351)
Ready Biodegradability Prediction: NO
Description of key information
Key study: Internationally accepted calculation method, EPI-Suite
EPA (USA). The substance is predicted to be not readily biodegradable
(BIOWIN v4.10).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
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