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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented GLP study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001

Materials and methods

Principles of method if other than guideline:
OECD 406 (skin Sensitisation)
GLP compliance:
yes
Type of study:
Buehler test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,18 Octadecanedioic acid
- Physical state: white solid
- Analytical purity: 100%

In vivo test system

Test animals

Species:
guinea pig
Strain:
other:
Sex:
female

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: dermal
Vehicle:
other: corn oil
Concentration / amount:
Inductions: 30 %
Challenge: 30 %
Challengeopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
other: corn oil
Concentration / amount:
Inductions: 30 %
Challenge: 30 %
No. of animals per dose:
30

Results and discussion

Any other information on results incl. tables

All test animals and controls showed no skin effects (0%). Not sensitizing in guinea pigs.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information