Registration Dossier
Registration Dossier
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EC number: 211-720-1 | CAS number: 691-37-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The results of a Reverse Mutagenicity test on Bacteria, an in-vitro Chromosome Abberation study using cultured mammalian cells and a mouse lymphoma assay on 4 -methylpent-1-ene were all negative. Hence, as the in vitro genotoxicity studies were negative and, in accordance with Regulation (EC) 1907/2006, investigation of germ cell mutagenicity in vivo is unnecessary.
Short description of key information:
Reverse Mutagenicity test on Bacteria of 4-methyl-1-pentene : Negative (OECD 471).
Chromosome Aberration study of 4-methyl-1-pentene using cultured mammalian cells : Negative (OECD 473).
4-methyl pent-1-ene: L5178Y TK +/- mouse lymphoma assay: Negative (OECD 476).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The test item is not considered to be mutagenic based upon the available in-vitro data and as the in vitro genotoxicity studies were negative investigation of germ cell mutagenicity in vivo is unnecessary according to Regulation (EC) 1907/2006.
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