Registration Dossier
Registration Dossier
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EC number: 211-720-1 | CAS number: 691-37-2
Endpoint summary
Administrative data
Description of key information
Non-corrosive to skin (OECD 431)
Non-irritating to skin (OECD 439)
Non-irritating to the eye (SkinEthic reconstructed human corneal epithelial model)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation/corrosion:
An in vitro skin corrosion study and in vitro skin irritation study using the Episkin T reconstituted human epidermis model have been performed (Warren 2010). These in vitro methods are validated methods for skin corrosion and irritation and allow full replacement of animal testing.
Eye irritation:
The test material is classified as flammable and, in accordance with Regulation (EC) 1907/2006, it is inappropriate to investigate eye irritation in vertebrate animals. However, results from an in vitro study provide useful confirmation that eye irritation is of minimal concern.
Justification for classification or non-classification
In vitro results indicate that it is unnecessary to classify the substance for skin corrosion, skin irritation or eye irritation under the terms of GHS as reflected by Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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