Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-415-3 | CAS number: 13776-88-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 May - 21 Jun 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Aluminium metaphosphate
- EC Number:
- 237-415-3
- EC Name:
- Aluminium metaphosphate
- Cas Number:
- 13776-88-0
- Molecular formula:
- Al.3HO3P
- IUPAC Name:
- aluminium metaphosphate
- Details on test material:
- - Name of test material (as cited in study report): Aluminium metaphosphate
- Physical state: white solid powder
- Analytical purity: >95%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Weight at study initiation: 190-250 g
- Fasting period before study: 3 h
- Housing: single-caged
- Diet: Common diet (pellets, ssniff Spezialdiäten GmbH, Germany), ad libitum
- Water: Tap water (drinking quality), ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-60
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 1 mL/100 g bw
MAXIMUM DOSE VOLUME APPLIED: 1 mL/100 g bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: A starting dose level of 300 mg/kg bw was used which is recommended in OECD 423 for animal welfare reasons when no toxicological information on the substance to be tested is available. - Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- control group: 3
test groups: 6 - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The body weight of all animals was determined at test start, 1 week after test start and at test end. The animals were observed daily for clinical symptoms.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Control group: no mortality occurred
300 mg/kg bw: 1/6 animals died on Day 2
2000 mg/kg bw: no mortality occurred - Clinical signs:
- other: Control group: no clinical signs of toxicity were observed. 300 mg/kg bw: 1/6 animals showed left forelimb in relieving posture at 0-4 h post-treatment. The same animal showed intense swelling of the left forelimb prior to death on Day 2. 2000 mg/kg bw: n
- Gross pathology:
- Control group: there were no abnormal findings at gross necropsy.
300 mg/kg bw: macroscopic findings in the animal found death on Day 2 included: perforation of the oesophagus (ca. 4 mm); rectum faeces not formed; moderate congestion hyperaemia in the spleen, liver and kidneys; high-grade congestion hyperaemia in the heart; moderate congestion hyperaemia, different blood distribution and low-grade oedema and emphysema in the lung.
2000 mg/kg bw: there were no abnormal findings at gross necropsy.
Any other information on results incl. tables
Table 1. Summary of mortality and clinical signs.
Dose level (mg/kg bw) |
Animal number |
Observation period |
|||
0-4 h |
Day 1-14 |
||||
Mortality |
Clinical signs |
Mortality |
Clinical signs |
||
Control |
1 |
no |
NAD |
no |
NAD |
2 |
no |
NAD |
no |
NAD |
|
3 |
no |
NAD |
no |
NAD |
|
300 |
1 |
no |
NAD |
no |
NAD |
2 |
no |
(1) |
yes, Day 2 |
(2) |
|
3 |
no |
NAD |
no |
NAD |
|
4 |
no |
NAD |
no |
NAD |
|
5 |
no |
NAD |
no |
NAD |
|
6 |
no |
NAD |
no |
NAD |
|
2000 |
1 |
no |
NAD |
no |
NAD |
2 |
no |
NAD |
no |
NAD |
|
3 |
no |
NAD |
no |
NAD |
|
4 |
no |
NAD |
no |
NAD |
|
5 |
no |
NAD |
no |
NAD |
|
6 |
no |
NAD |
no |
NAD |
NAD: no abnormality detected
(1): left forelimb in relieving posture
(2): intense swelling of left forelimb
Table 2. Summary of body weight (gain).
Dose level (mg/kg bw) |
Animal number |
Body weight (gain) (g) |
||||
Day 0 |
Day 7 |
Day 0-7 |
Day 14 |
Day 0-14 |
||
Control |
1 |
197.7 |
214.5 |
16.8 |
206.3 |
8.6 |
2 |
209.8 |
229.6 |
19.8 |
237.3 |
27.5 |
|
3 |
201.6 |
221.2 |
19.6 |
235.7 |
34.1 |
|
300 |
1 |
195.5 |
218.8 |
23.3 |
225.8 |
30.3 |
2 |
216.5 |
- |
- |
- |
- |
|
3 |
219.2 |
242.3 |
23.1 |
255.4 |
36.2 |
|
4 |
247.4 |
276.1 |
28.7 |
280.1 |
32.7 |
|
5 |
201.7 |
220.3 |
18.6 |
226.2 |
24.5 |
|
6 |
230.1 |
258.6 |
28.5 |
264.0 |
33.9 |
|
2000 |
1 |
187.3 |
211.8 |
24.5 |
227.7 |
40.4 |
2 |
193.7 |
224.5 |
30.8 |
241.5 |
47.8 |
|
3 |
192.7 |
229.0 |
36.3 |
243.9 |
51.2 |
|
4 |
202.0 |
238.2 |
36.2 |
263.0 |
61.0 |
|
5 |
194.4 |
220.6 |
26.6 |
236.4 |
42.0 |
|
6 |
195.0 |
224.3 |
29.3 |
245.3 |
50.3 |
Table 3. Summary of necropsy findings.
Dose level (mg/kg bw) |
Animal number |
Necropsy findings |
Control |
1 |
NAD |
2 |
NAD |
|
3 |
NAD |
|
300 |
1 |
NAD |
2 |
(1) |
|
3 |
NAD |
|
4 |
NAD |
|
5 |
NAD |
|
6 |
NAD |
|
2000 |
1 |
NAD |
2 |
NAD |
|
3 |
NAD |
|
4 |
NAD |
|
5 |
NAD |
|
6 |
NAD |
NAD: no abnormality detected
(1):
Oesophagus: perforation (ca. 4 mm)
Rectum: faeces not formed
Spleen: moderate congestion hyperaemia
Liver: moderate congestion hyperaemia
Lungs: moderate congestion hyperaemia, different blood distribution, low-grade oedem and emphysema
Heart: high-grade congestion hyperaemia
Kidneys: moderate congestion hyperaemia
Macroscopic suspected diagnosis: oesophagus perforation with food dislocation.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- The oral LD50 of the test material in female rats was determined to be >2000 mg/kg bw. One animal given the test material at 300 mg/kg bw showed adverse clinical signs and died on Day 2 post-treatment. Necropsy findings led to the diagnosis "oesophagus perforation with food dislocation" and further to the conclusion that the animal died due to a treatment mistake and not caused by the test material. Except for this incident, there were no test material-related mortalities, clinical signs of systemic toxicity, adverse effects on body weight (gain) or abnormal necropsy findings. Therefore, the material does not fulfil the criteria for classification according to Regulation (EC) No 1272/2008 (CLP) and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), and is thus considered to be not acutely toxic by the oral route.
CLP: not classified
GHS: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.