Registration Dossier
Registration Dossier
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EC number: 205-775-0 | CAS number: 150-84-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable data, no GLP, TS purity not specified
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- acute oral toxicity study
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Citronellyl acetate
- EC Number:
- 205-775-0
- EC Name:
- Citronellyl acetate
- Cas Number:
- 150-84-5
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yl acetate
- Test material form:
- not specified
- Details on test material:
- - Lot/batch No.: RIFM-70-462
No further details provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 16 h
TEST ANIMALS
- Weight at study initiation: 150 - 208 g
- Acclimation period: 5 d before beginning of study
- Housing: stock cages
- Housing after dosing: individually in wire-mesh cages
- Food and water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 3000, 4600, 6800, 10200 mg/kg bw
- No. of animals per sex per dose:
- 2 male and 2 female per dose
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: mortality, clinical signs, initial and final body weight - Statistics:
- Weil and Thompson methods
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 800 mg/kg bw
- Remarks on result:
- other: Standard deviation: +/- 800 mg/kg bw
- Mortality:
- 3000 mg/kg bw: 0/4 deaths
4600 mg/kg bw: 0/4 deaths
6800 mg/kg bw: 2/4 deaths
10200 mg/kg bw: 4/4 deaths - Clinical signs:
- 3000 mg/kg: hypoactivity, ruffed fur
4600 mg/kg bw: hypoactivity, ruffed fur, muscular weakness
6800 mg/kg bw: hypoactivity, muscular weakness, prostration, diarrhea, ruffed fur
10200 mg/kg bw: hypoactivity, muscular weakness, prostration, diarrhea, ruffed fur - Body weight:
- No evident effect on body weights (body weights were only assessed in survivors)
- Gross pathology:
- Animals sacrificed: no gross findings
Animals found dead: gastroenteritis, pale livers, pale kidneys, hemorrhages in the stomachs
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
