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EC number: 425-220-8 | CAS number: 5945-33-5
According to OECD TG 406, Maximisation test of Magnusson and Kligman was accomplished and concluded that test material did not induce skin sensitisation in guinea pigs (Driscoll, 1997). Although the GPMT was not recomended by REACH now, but the existing data provided sufficient and valid results to make a reliable predication .Moreover,the laboratory facilities which complying with OECD Principles of Good Laboratory Practice were utilized in order to ensure the consistency and reliability for the tests.
This study was utilized as a key study in substance sensitisation evaluation due to the high adequation, reliablility and relevance to this element.Therefore, no further in vivo testing is needed for hazard identification such as LLNA due to animal welfare reasons.
According to the existing studies on acute skin sensitisation test in laboratory animals, which provide sound conclusive evidence that the
substance (CAS:5945-33-5 ) was considered as a non-skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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