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EC number: 219-606-3 | CAS number: 2478-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 9888
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Test substance: Butanediolmonoacrylate
- Chemical name: 2-Propenoic acid, 4-hydroxy ester - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: activated sludge from an industrial waste water treatment plant (BASF AG).
- Concentration of sludge: 1 g/L dry matter. - Duration of test (contact time):
- 8 d
- Initial conc.:
- 737 mg/L
- Based on:
- test mat.
- Initial conc.:
- 400 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Parameter:
- % degradation (DOC removal)
- Value:
- 90 - 100
- Sampling time:
- 8 d
- Details on results:
- DOC removal (%):
- 0 % after 0 day
- 2 % after 0.125 day
- 7 % after 1 day
- 63 % after 4 days
- 79 % after 6 days
- 92 % after 8 days
Degradation products: not measured - Validity criteria fulfilled:
- not specified
- Interpretation of results:
- inherently biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 Dec 2004 to 31 Dec 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Version / remarks:
- 1993
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- Version / remarks:
- Official Journal of the European Communities L383 A, 35th year, 29 December 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 7827 (Evaluation in an Aqueous Medium of the "Ultimate" Aerobic Biodegradability of Organic Compounds - Method by Analysis of Dissolved Organic Carbon (DOC))
- Version / remarks:
- 1994
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Test substance: Butanediolmonoacrylate
- Chemical name: 2-propenoic acid, 4-hydroxybutylester
- Batch number: 010078 EDA 0
- Aggregate state: liquid
- Date of production: 10 July 2004
- Purity of the test substance: 99.3 corrected peak area-%
- Impurities: water 0.04 g/100g
- Stability: guaranteed by sponsor
- Expiry date: January 10, 2005 - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge from a laboratory wastewater plant treating municipal sewage was used. The concentration of activated sludge in the test assay was 30 mg/L (dry substance). The inoculum was pre-aerated for about 24 hours before the start of the test.
- Duration of test (contact time):
- 21 d
- Initial conc.:
- 32.3 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Test temperature: 22 ± 2 °C
- pH: 7.4 - 7.8
- pH adjusted: yes
- Analytical method: DOC elimination
CONTROLS
- Inhibition control (with reference and test substance, with inoculum)
- Physico-chemical (abiotic) elimination control (with test substance, without inoculum)
- Adsorption control (with test substance, with inoculum*)
* Bacterial activity was stopped by addition of mercury chloride solution. - Reference substance:
- aniline
- Test performance:
- VALIDITY CRITERIA
- Deviation of the degradation degree of the test substance in the plateau phase was 20 %.
- Degradation degree of the reference substance was >70 % after 14 days (see 'Results with reference substance')
- Degradation degree in the inhibition control was >35 % after 14 days. - Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- >= 90 - <= 100
- Sampling time:
- 21 d
- Details on results:
- The adaption phase was 2 days. The degree of biodegradation increased from 24% at day 3 in a dose-dependent manner to approximately 100% after 14 days, see 'Any other information on results incl. tables'. The test was terminated after 21 days, as the test substance was completely mineralized (the duration of the degradation phase was approximately 12 days). The 10-day window was met.
CONTROLS
- Inhibition control: The inhibition control was degraded for 90 - 100% after 14 days
- Physico-chemical (abiotic) elimination of the test substance (% DOC) was < 10 at the end of the test
- Elimination of the test substance by adsorption (% DOC) was < 10 after 5 days
- Kinetic control (DOC degree in %): 0 % after 1 day and 96 % after 3 days - Results with reference substance:
- Reference substance (aniline): 90 - 100 % degradation after 14 days.
- Validity criteria fulfilled:
- yes
- Remarks:
- see 'Test performance'
- Interpretation of results:
- readily biodegradable
Referenceopen allclose all
Table: DOC-degree (%)
Day |
RS |
IH |
TS mv |
0 |
0 |
0 |
0 |
1 |
-4 |
1 |
4 |
3 |
96 |
12 |
24 |
5 |
98 |
80 |
59 |
7 |
95 |
88 |
76 |
10 |
92 |
95 |
95 |
14 |
99 |
97 |
100 |
17 |
99 |
98 |
98 |
20 |
98 |
98 |
98 |
21 |
98 |
98 |
99 |
RS: Reference substance
IH: Inhibition control
TS mv: Test substance, mean value
Description of key information
The substance is readily biodegradable as observed in a screening study according to OECD TG 301A.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Two screening studies on the biodegradability of the test substance are availabe: one ready test and one inherent test.
The ready test was selected as key study, as this study was performed most recent, was GLP-compliant and performed according to OECD guidelines. The biodegradation potential of the substance in water in a screening study according to OECD TG 301A (DOC Die Away Test) and in compliance with GLP criteria (BASF, 2004). In this study 20 mg/L test substance (expressed as DOC) was inoculated with non-adapted activated sludge from a domestic sewage treatment plant for 21 days under aerobic conditions. The adaption phase was 2 days. The degree of biodegradation increased from 24% at day 3 in a dose-dependent manner to approximately 100% after 14 days. Therefore the test was aborted early, after 21 days (the duration of the degradation phase was approximately 12 days). The 10-day window criterion was met. The inhibition control was degraded for 90 - 100% after 14 days. Based on these results, the substance was assessed to be readily biodegradable.
The study selected as supporting study, determined the inherent biodegradability of the test substance according to OECD 302B (BASF, 1978). No detailed documentation is available. In this study, 737 mg/L of test substance (corresponding to 400 mg/L DOC) was inoculated with activated sludge from an industrial waste water treatment plant. The degree of biodegradation (based on DOC-removal) was 7% after 1 day, 63% after 4 days and increased to 79% and 92% after 6 and 8 days, respectively. Based on these results, the substance was assessed to be inherently biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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