Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

Reactive Red 239 did not cause acute toxic effects after oral and dermal administration. The test substance is neither irritant to skin nor eyes, nor shows sensitizing effects. In the 28 days subacute toxicity study in the rat, no treatment-related clinical signs and no signs of systemic toxicity were observed throughout the study. The administration of Reactive Red 239 resulted in a dose-dependent incorporation of the substance in the proximal tubule of the kidneys without causing changes in renal morphology or showing evidence of impaired renal function in the clinical chemistry parameters. Consequently, the 'no observed effect level' (NOEL) in this study is 200 mg/kg bw/day. However, signs of toxic effects were also not seen in the 1000 mg/kg bw group, which was defined as the 'no observed adverse effect level' (NOAEL).

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

Reactive Red 239 did not cause acute toxic effects after oral and dermal administration. The test substance is neither irritant to skin nor eyes, nor shows sensitizing effects. In the 28 days subacute toxicity study in the rat, no treatment-related clinical signs and no signs of systemic toxicity were observed throughout the study. The administration of Reactive Red 239 resulted in a dose-dependent incorporation of the substance in the proximal tubule of the kidneys without causing changes in renal morphology or showingevidence of impaired renal function in the clinical chemistry parameters.Consequently, the 'no observed effect level' (NOEL) in this study is 200 mg/kg bw/day. However, signs of toxic effects were also not seen in the 1000 mg/kg bw group, which was defined as the 'no observed adverse effect level' (NOAEL).