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EC number: 682-239-6 | CAS number: 1190931-41-9
Endpoint summary
Administrative data
Description of key information
The potential oral acute toxicity of F-DIOX acid was evaluated through the Read Across approach with cC6O4 ammonium salt.
Basing on experimental study of acute oral toxicity performed on cC6O4 ammonium salt, F-DIOX acid would be classified according to the Regulation (EC) No. 1272/2008 as following:
Acute oral toxicity - Category 4
Hazard statement (Oral): H302: Harmful if swallowed
Key value for chemical safety assessment
Additional information
F-DIOX acid is a carboxylic acid used as chemical intermediate in the manufacturing process of cC6O4 ammonium salt.
In order to evaluate the potential oral acute toxicity of F- DIOX acid it was deemed appropriate to use the Read Across approach based on the experimental study performed on cC6O4 ammonium salt by virtue of similarity of chemical structure between F- DIOX acid and cC6O4 ammonium salt (CAS no: 1190931-27-1).
C6O4 ammonium salt is the ammonium salt of F-Diox acid therefore C6O4 ammonium salt differ from F-DIOX acid only for the presence of the cationic part NH4+.
C6O4 ammonium salt is an highly soluble salt. During the oral toxicity study it was administered by gavage (vehicle: water). At the pH of gastric fluids C6O4 ammonium salt is assumed as completely dissociated, therefore the anionic form is probably the species systemically available and responsible of the observed toxicity.
F-DIOX acid is an organic strong acid. The product in aqueous media is in equilibrium with its anion. The pKa of the carboxylic acid is 1.61-1.99, less than 3 (gastric pH), therefore the anion is expected to be predominated at physiological pH.
Basing on consideration that the active species after oral administration is the same both for C6O4 ammonium salt and for F-DIOX acid, it is deemed appropriate to assume the same level of toxicity between the two substances.
The results of the oral toxicity study indicate that cC6O4 ammonium salt has a toxic effect on the rat following oral administration of a single dose at a level of 2000 mg(dry salt)/kg. The mortality pattern demonstrates the LD50 to be greater than 300 mg(dry salt)/kg but less than 2000 mg(dry salt)/kg body weight.
Basing on considerations above reported, for F-DIOX acid is expected the same degree of oral toxicity than for cC6O4 ammonium salt.
Justification for classification or non-classification
Classification for ORAL TOXICITY:
The classification is based on the Read Across approach with cC6O4 ammonium salt above discussed.
Basing on experimental study of acute oral toxicity performed on cC6O4 ammonium salt, F-Diox acid would be classified according to the Regulation (EC) No. 1272/2008 as following:
Acute oral toxicity - Category 4
Hazard statement (Oral): H302: Harmful if swallowed
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