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EC number: 610-848-9 | CAS number: 52479-58-0
A developmental toxicity study was performed with TMP EO according to OECD TG 414. Twenty-five inseminated female Wistar rats each were treated daily orally by gavage with the test substance in deminaralized water from day 6 to day 20 p.c. in the following doses: 0, 100, 300, and 1000 mg/kg bw/d, respectively. The fetuses were delivered by cesarean section on day 21 of gestation. Investigation was performed on general tolerance of the test substance by the females as well as on its effect on intrauterine development. Appearance, behaviour, mortality, absolute and corrected body weight gains, food intake, water intake, and fecal and urinary excretions were unaffected at dose levels up to and including 1000 mg/kg bw/d. No treatment related gross pathological findings occurred at dose levels up to and including 1000 mg/kg bw/d.
The gestation rate, appearance and weights of placentas, postimplantation loss and correspondingly the number of fetuses, fetal sex distribution, and fetal weights were unaffected by treatment at dose levels up to and including 1000 mg/kg.
A treatment related effect on malformations, external, visceral, and skeletal (including cartilage) deviations was not evident at dose levels up to and including 1000 mg/kg.
Summarizing and evaluating all data investigated the following no-observed-adverse-effect levels (NOAELs) were determined: for maternal toxicity 1000 mg/kg bw, for developmental toxicity 1000 mg/kg bw.
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