Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: secondary information made available in a report of "Berufsgenossenschaft der chemischen Industrie", 2000

Data source

Reference
Reference Type:
secondary source
Title:
Tetrafluoroboric acid and its salts - Toxicological evaluation
Author:
Anonymous
Year:
2000
Bibliographic source:
BG Chemie InfoCenter Toxikologische Bewertungen (www.bgchemie.de)
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrafluoroboric acid
EC Number:
240-898-3
EC Name:
Tetrafluoroboric acid
Cas Number:
16872-11-0
Molecular formula:
BF4.H
IUPAC Name:
tetrafluoroborate

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
A 51.5% aqueous solution of tetrafluoroboric acid was used for testing
Doses:
10, 100, 464 and 1000 mg/kg body weight
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 464 - <= 1 000 mg/kg bw
Based on:
dissolved
Remarks on result:
other: The doses refers to 51.5% of an aqueous tetrafluoroboric acid solution
Mortality:
The signs of toxicity were reversible after 24 hours
Clinical signs:
other: The 10 mg/kg body weight dose was tolerated without signs of toxicity. Following 100 mg/kg body weight, dyspnoea, sedation and lack of appetite were observed, and in the males, half-closed eyes. The signs of toxicity were reversible after 24 hours. Follow

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information 51.5 % aqueous solution of tetrafluoroboric acid Criteria used for interpretation of results: EU
Conclusions:
The LD50 of 51-percent tetrafluoroboric acid was between 464 and 1000 mg/kg body weight and therefore, harmful if swallowed.