Registration Dossier
Registration Dossier
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EC number: 273-734-4 | CAS number: 69012-34-6 By-product from open-hearth steelmaking. Consists of oxides of calcium, iron, silicon and vanadium.
Endpoint summary
Administrative data
Description of key information
Skin irritation and corrosion was tested in two individual in-vitro tests with negative findings. The substance is not irritant to skin and eyes. Respiratory irritation is not applicable, as exposure via inhalation is not expected to this transported intermediate under normal operating conditions and acute inhalation toxicity data are not required under Regulation (EC) 1907/2006.
. Therefore, the additional labeling is not required.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
Anin vitroskin irritation study (EpiSkinTM) was performed with the substance (Heppenheimer, 2010), and results indicate that it is not irritant to skin.
Eye irritation
An acute eye irritation / corrosion test according to OECD 405 (Leuschner, 2010) was performed with the substance, and results indicate that it is not irritant to eyes.
Justification for classification or non-classification
Skin irritation:
The study by Heppenheimer (2010) is an in vitro skin irritation study, is considered the key study for skin irritation, and will be used for classification.
After treatment with the test item slags, steelmaking, vanadium, the relative absorbance values did not decrease (106.6 %). Therefore, the test item is not considered to possess an irritant potential. The substance was not tested irritant to skin, and does not need to be classified or labelled for skin irritation.
Eye irritation:
The study by Leuschner (2010) is an in vivo eye irritation study (OECD 405), is considered the key study for eye irritation, and will be used for classification. The overall irritation results are as follows:
Opacity (cornea and iris), 1h after application: mean score=0.0
Conjunctival chemosis, 1h after application: mean score=0.33
Conjunctival chemosis, 24, 48 and 72h after application: mean score=0.0
Conjunctival redness, 1h after application: mean score=1.33
Conjunctival redness, 24, 48 and 72h after application: mean score=0.66
Conjunctival redness, 6d after application: mean score=0.0
Accordingly, the substance was not tested irritant to eyes, and does not need to be classified or labelled for eye irritation.
Respiratory irritation:
Respiratory irritation is not applicable, as exposure via inhalation is not expected to this transported intermediate under normal operating conditions and acute inhalation toxicity data are not required under Regulation (EC) 1907/2006.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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