Registration Dossier
Registration Dossier
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EC number: 925-312-2 | CAS number: 1184044-93-6
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- bis(acetic acid); ethyl 3-{1-[1-methyl-2-({[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-1,3-benzodiazol-5-yl]-N-(pyridin-2-yl)formamido}propanoate
- EC Number:
- 925-312-2
- Cas Number:
- 1184044-93-6
- Molecular formula:
- C28 H27 N7 O5 x 2 C2 H4 O2
- IUPAC Name:
- bis(acetic acid); ethyl 3-{1-[1-methyl-2-({[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-1,3-benzodiazol-5-yl]-N-(pyridin-2-yl)formamido}propanoate
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- ca. 2.538 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 4.5
- Remarks on result:
- other: requirements of EC method A.6 and OECD 105 concerning solubility criteria are fulfilled.
Applicant's summary and conclusion
- Conclusions:
- The solubility of BIBR 1048 Oxa Amidin was determined in ultra-pure water in equilibrium with atmospheric carbon dioxide at a temperature of 20 ± 0.5° C. Determined pH value is 4.5 with Mean solubility of 2.538 mg/L.
The results indicate the required reproducibility (relative standard deviation below 30%) and no tendency to increasing values, when the test time was prolonged.
The mean values obtained from the two test with different flows did not differ by more than 30%.
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