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Diss Factsheets
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EC number: 205-538-1 | CAS number: 142-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Toxicokinetic Assessment
- Adequacy of study:
- key study
- Study period:
- August 2010 - September 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Toxicokinetic Assessment by a certified toxicologist.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance
- Qualifier:
- according to guideline
- Guideline:
- other: ECB EU Technical Guidance Document on Risk Assessment, 2003
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium hydrogen glutamate
- EC Number:
- 205-538-1
- EC Name:
- Sodium hydrogen glutamate
- Cas Number:
- 142-47-2
- Molecular formula:
- C5H8NNaO4
- IUPAC Name:
- sodium hydrogen 2-aminopentanedioate
- Details on test material:
- - Name of test material (as cited in study report): Monosodium L-Glutamate monohydrate
- Description: White powder
Constituent 1
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- absorption oral 10%, absorption dermal 10% and absorption inhalation 100%
Any other information on results incl. tables
TOXICOKINETIC ASSESSMENT
The dicarboxylic amino acid L-Glutamate is a major oxidative fuel for the gut. In addition, LGlutamate is an important precursor for other biologically active molecules, including glutathione, proline and arginine, and also functions as a key neurotransmitter (Reeds et al., 2000). Several studies have shown that L-Glutamate is extensively metabolized by the intestinal enterocytes. Studies by Windmueller and Spaeth using an in situ perfused rat intestine established that only small fractions of luminally administered L-Glutamate are absorbed into the mesenteric venous blood.(Windmueller and Spaeth, 1975, 1980). Subsequent studies in young pigs, preterm infants and adult humans have confirmed that dietary L-Glutamate is extensively metabolized by the intestine and that oxidation to CO2 is a major metabolic fate (Battezzati et al., 1995; Riedij et al., 2007; Stoll et al., 1999). The gut capacity for metabolism of dietary L-Glutamate is substantial, even when the intake is in excess of the normal level. Even when the dietary intake is increased three to four fold, a majority of the dietary L-Glutamate intake is metabolized by the gut, either for generation of ATP or conversion into other amino acids. Apart from CO2, most of the end-products of L-Glutamate metabolism are non-essential amino acids (Burrin et al., 2008). For risk assessment purposes oral absorption of Glutamate is set at 10%.
L-Glutamate and -ketoglutarate, an intermediate in the Krebs cycle, are interconvertible by transamination. L-Glutamate can therefore enter the Krebs cycle for energy metabolism. (Burrin et al., 2008).
Due to the low vapour pressure (< 0.00147 Pa) of the substance it is not to be expected that Glutamate will reach the nasopharyncheal region or subsequently the tracheobronchial or pulmonary region. Moreover, Monosodium L-Glutamate has a large MMAD of 148 μm and only 4.3% of the particles is below 10 μm. However, being a very hydrophilic substance with a molecular weight below 200, any Monosodium L-Glutamate reaching the lungs might be absorbed through aqueous pores. (ECHA, 2008) For risk assessment purposes, although it is unlikely that Monosodium L-Glutamate will be available to a high extent after inhalation via the
lungs due to the low vapour pressure and high MMAD, the inhalation absorption of Monosodium L-Glutamate is set at 100%.
Monosodium L-Glutamate with high water solubility and the log P value below 0 may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Therefore, 10% dermal absorption of Monosodium L-Glutamate is proposed for risk assessment purposes.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: The absorption factors for risk assessment purposes have been set by a certified toxicologist: absorption oral 10%, absorption dermal 10% and absorption inhalation 100%
For risk assessment purposes:
Absorption oral = 10%
Absorption dermal = 10%
Absorption inhalation = 100%
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